Advanced engineering strategies in human organoids for tissue repair and regeneration.
- 1Department of Dermatology, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, No. 20 Xisi Road, Chongchuan District, Nantong 226001, China.
- 2Department of Rheumatology, Research Center of Immunology, Affiliated Hospital of Nantong University, Medical School of Nantong University, No. 20 Xisi Road, Chongchuan District, Nantong 226001, China.
Abstract
Tissue damage and functional disorders due to diseases or trauma can lead to irreversible organ failure. Conventional treatment strategies such as organ transplantation or stem cell therapy are often limited by immune rejection, donor shortages, and poor regenerative effects. Organoids, 3D miniature tissues derived from stem cells, can provide a promising approach for tissue repair and regeneration by recapitulating the complex structure and functional properties of native organs with high plasticity, scalability, and physiological relevance. In this review, we present novel engineering approaches to human organoids such as generation, optimization, and translational applications for tissue repair. We then introduce core technologies including organoid-on-chip, hydrogels, and 3D bioprinting, which collectively address the challenges such as tissue immaturity, inadequate vascularization, and poor host integration. We also discuss applications of engineered organoids to repair multiple tissues (e.g. heart, lung, brain, bone, and skin) and summarize recent advances in preclinical models and their potential clinical translational applications. Finally, we discuss key challenges for organoid-based therapy including functional maturation; integration with vascular, neural, and immune systems; complexity of reproducing native biomechanical environments; and ethical concerns, as well as possible solutions and directions for their application in regenerative medicine.
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BibTeX
@article{zhang2026advanced,
title = {{Advanced engineering strategies in human organoids for tissue repair and regeneration.}},
author = {Hao Zhang and Nengjie Yang and Yuqi Wu and Siyu Chen and Ya Wen and Yujuan Zhu and Xiaodong Chen},
journal = {Burns \& trauma},
year = {2026},
month = oct,
doi = {10.1093/burnst/tkag065},
url = {https://europepmc.org/article/MED/42974060},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Advanced engineering strategies in human organoids for tissue repair and regeneration.
AU - Hao Zhang
AU - Nengjie Yang
AU - Yuqi Wu
AU - Siyu Chen
AU - Ya Wen
AU - Yujuan Zhu
AU - Xiaodong Chen
PY - 2026
DA - 2026/10/06
JO - Burns & trauma
DO - 10.1093/burnst/tkag065
UR - https://europepmc.org/article/MED/42974060
AB - Tissue damage and functional disorders due to diseases or trauma can lead to irreversible organ failure. Conventional treatment strategies such as organ transplantation or stem cell therapy are often limited by immune rejection, donor shortages, and poor regenerative effects. Organoids, 3D miniature tissues derived from stem cells, can provide a promising approach for tissue repair and regeneration by recapitulating the complex structure and functional properties of native organs with high plasticity, scalability, and physiological relevance. In this review, we present novel engineering approaches to human organoids such as generation, optimization, and translational applications for tissue repair. We then introduce core technologies including organoid-on-chip, hydrogels, and 3D bioprinting, which collectively address the challenges such as tissue immaturity, inadequate vascularization, and poor host integration. We also discuss applications of engineered organoids to repair multiple tissues (e.g. heart, lung, brain, bone, and skin) and summarize recent advances in preclinical models and their potential clinical translational applications. Finally, we discuss key challenges for organoid-based therapy including functional maturation; integration with vascular, neural, and immune systems; complexity of reproducing native biomechanical environments; and ethical concerns, as well as possible solutions and directions for their application in regenerative medicine.
SN - 2321-3868
SN - 2321-3876
ER -