Pulmonary arterial hypertension-associated cerebellar impairment extends evidence linking cardiometabolic and neurodegenerative diseases.
- 1Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, UW Medicine Diabetes Institute, and.
- 2Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
Abstract
Growing evidence shows that the risk of cognitive impairment is increased across a range of metabolic and cardiovascular diseases, but underlying mechanisms remain poorly understood. One possibility involves activation of microglia, a glial cell type of the central nervous system with morphological and transcriptional features comparable to resident macrophages in other tissues that plays specialized roles in supporting neuronal and brain function. Combining clinical investigation in pulmonary arterial hypertension (PAH) cohorts with mouse model and microglial cell culture studies, a study by Okawa, Shi, and colleagues in this issue of the JCI adds compelling, albeit indirect, evidence linking impaired lysosomal lipid handling in both endothelial cells and microglia to a specific neurological disorder associated with PAH. The findings open opportunities for understanding how cardiopulmonary disease predisposes to neurodegeneration.
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BibTeX
@article{schwartz2026pulmonary,
title = {{Pulmonary arterial hypertension-associated cerebellar impairment extends evidence linking cardiometabolic and neurodegenerative diseases.}},
author = {Michael W Schwartz and Karin E Bornfeldt},
journal = {The Journal of clinical investigation},
year = {2026},
month = nov,
doi = {10.1172/jci212006},
url = {https://europepmc.org/article/MED/42969234},
note = {CC BY},
}
RIS
TY - JOUR
TI - Pulmonary arterial hypertension-associated cerebellar impairment extends evidence linking cardiometabolic and neurodegenerative diseases.
AU - Michael W Schwartz
AU - Karin E Bornfeldt
PY - 2026
DA - 2026/11/02
JO - The Journal of clinical investigation
DO - 10.1172/jci212006
UR - https://europepmc.org/article/MED/42969234
AB - Growing evidence shows that the risk of cognitive impairment is increased across a range of metabolic and cardiovascular diseases, but underlying mechanisms remain poorly understood. One possibility involves activation of microglia, a glial cell type of the central nervous system with morphological and transcriptional features comparable to resident macrophages in other tissues that plays specialized roles in supporting neuronal and brain function. Combining clinical investigation in pulmonary arterial hypertension (PAH) cohorts with mouse model and microglial cell culture studies, a study by Okawa, Shi, and colleagues in this issue of the JCI adds compelling, albeit indirect, evidence linking impaired lysosomal lipid handling in both endothelial cells and microglia to a specific neurological disorder associated with PAH. The findings open opportunities for understanding how cardiopulmonary disease predisposes to neurodegeneration.
SN - 0021-9738
SN - 1558-8238
ER -