Rapid and Reusable Amino Acid–Derived MOFs for the Removal of Estrogenic Hormones From Real Water Matrices
- 1Instituto de Ciencia Molecular (ICMol) Universidad de Valencia Valencia Spain
- 2Department of Analytical Chemistry University of Valencia Valencia Spain
- 3Dipartimento di Chimica e Tecnologie Chimiche (CTC) Università della Calabria Cosenza Italy
Abstract
Estrogenic hormones are potent endocrine‐disrupting contaminants that are inefficiently removed by conventional wastewater treatment processes. Herein, we evaluate a family of isoreticular amino‐acid–derived metal–organic frameworks (MOFs), including multivariate variants, for the simultaneous capture of estrone (E1), 17β‐estradiol (E2), estriol (E3), and 17α‐ethinylestradiol (EE2) from water. Using a solid‐phase extraction configuration, a leucine‐based oxamidato MOF emerges as a highly efficient sorbent, achieving >90%–95% removal of all four hormones within 30 s in a single loading step, representing one of the fastest simultaneous estrogen capture systems reported to date under SPE conditions. This material exhibits exceptional regenerability, enabling near‐quantitative desorption under mild conditions with minimal solvent consumption (1 mL methanol), and stable performance over at least ten reuse cycles. Notably, comparable capture efficiencies are maintained in real river‐water samples, demonstrating robustness toward complex aqueous matrices. The crystal structure of a host–guest aggregate confirms estrogen encapsulation within the flexible framework, providing direct structural insight into the origin of the high capture efficiency. These results identify amino‐acid–based MOFs as a highly competitive platform for rapid, regenerable, and selective estrogen capture, combining excellent performance with valuable structural insight into host–guest interactions.
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BibTeX
@article{garcia2026rapid,
title = {{Rapid and Reusable Amino Acid–Derived MOFs for the Removal of Estrogenic Hormones From Real Water Matrices}},
author = {Lidia García and Alejandro Cortés‐Villena and Héctor Martínez Pérez‐Cejuela and José Manuel Herrero‐Martínez and Jesús Ferrando‐Soria and Thais Grancha and Donatella Armentano and Emilio Pardo},
journal = {Chemistry (Weinheim an Der Bergstrasse, Germany)},
year = {2026},
month = aug,
doi = {10.1002/chem.71554},
url = {https://doi.org/10.1002/chem.71554},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Rapid and Reusable Amino Acid–Derived MOFs for the Removal of Estrogenic Hormones From Real Water Matrices
AU - Lidia García
AU - Alejandro Cortés‐Villena
AU - Héctor Martínez Pérez‐Cejuela
AU - José Manuel Herrero‐Martínez
AU - Jesús Ferrando‐Soria
AU - Thais Grancha
AU - Donatella Armentano
AU - Emilio Pardo
PY - 2026
DA - 2026/08/13
JO - Chemistry (Weinheim an Der Bergstrasse, Germany)
DO - 10.1002/chem.71554
UR - https://doi.org/10.1002/chem.71554
AB - Estrogenic hormones are potent endocrine‐disrupting contaminants that are inefficiently removed by conventional wastewater treatment processes. Herein, we evaluate a family of isoreticular amino‐acid–derived metal–organic frameworks (MOFs), including multivariate variants, for the simultaneous capture of estrone (E1), 17β‐estradiol (E2), estriol (E3), and 17α‐ethinylestradiol (EE2) from water. Using a solid‐phase extraction configuration, a leucine‐based oxamidato MOF emerges as a highly efficient sorbent, achieving >90%–95% removal of all four hormones within 30 s in a single loading step, representing one of the fastest simultaneous estrogen capture systems reported to date under SPE conditions. This material exhibits exceptional regenerability, enabling near‐quantitative desorption under mild conditions with minimal solvent consumption (1 mL methanol), and stable performance over at least ten reuse cycles. Notably, comparable capture efficiencies are maintained in real river‐water samples, demonstrating robustness toward complex aqueous matrices. The crystal structure of a host–guest aggregate confirms estrogen encapsulation within the flexible framework, providing direct structural insight into the origin of the high capture efficiency. These results identify amino‐acid–based MOFs as a highly competitive platform for rapid, regenerable, and selective estrogen capture, combining excellent performance with valuable structural insight into host–guest interactions.
SN - 0947-6539
SN - 1521-3765
ER -