Peer-reviewedCC BY-NC 4.0International Journal of Surgical Pathology
Uncommon Tumor, Unusual Site, and Unconventional Behavior: Report of a Gastric Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor (CoGNET) With Metastases
4 affiliations
- 1Department of Pathology, University of Missouri Hospital, Columbia, MO, USA
- 2Department of Nuclear Medicine, Washington University in St. Louis, St. Louis, MO, USA
- 3Department of Medical Oncology, Washington University in St Louis and Siteman Cancer Center, St Louis, MO, USA
- 4Department of Pathology, Cooper University Health Care, Camden, NJ, USA
Abstract
With the 2022 WHO Classification of Neuroendocrine Neoplasms 1 came an important distinction between epithelial and non-epithelial neoplasms, and the possibility of composite tumor in certain organs, including the duodenum, the spine and the middle ear. In particular, the formerly termed gangliocytic paraganglioma of the duodenum has been renamed as “composite gangliocytoma/neuroma and neuroendocrine tumor (CoGNET).” We present an unusual CoGNET arising in the stomach, displaying distinctive histomorphologies in primary tumor and metastases. Additionally, we discuss diagnostic pitfalls and highlight the importance of recognizing the combined features that can be seen in this rare, potentially malignant, entity.
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BibTeX
@article{dessain2026uncommon,
title = {{Uncommon Tumor, Unusual Site, and Unconventional Behavior: Report of a Gastric Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor (CoGNET) With Metastases}},
author = {Alicia Dessain and Vikas Prasad and Nikolaos Trikalinos and Pooja Navale},
journal = {International Journal of Surgical Pathology},
year = {2026},
month = jun,
doi = {10.1177/10668969261457873},
url = {https://doi.org/10.1177/10668969261457873},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Uncommon Tumor, Unusual Site, and Unconventional Behavior: Report of a Gastric Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor (CoGNET) With Metastases
AU - Alicia Dessain
AU - Vikas Prasad
AU - Nikolaos Trikalinos
AU - Pooja Navale
PY - 2026
DA - 2026/06/16
JO - International Journal of Surgical Pathology
DO - 10.1177/10668969261457873
UR - https://doi.org/10.1177/10668969261457873
AB - With the 2022 WHO Classification of Neuroendocrine Neoplasms 1 came an important distinction between epithelial and non-epithelial neoplasms, and the possibility of composite tumor in certain organs, including the duodenum, the spine and the middle ear. In particular, the formerly termed gangliocytic paraganglioma of the duodenum has been renamed as “composite gangliocytoma/neuroma and neuroendocrine tumor (CoGNET).” We present an unusual CoGNET arising in the stomach, displaying distinctive histomorphologies in primary tumor and metastases. Additionally, we discuss diagnostic pitfalls and highlight the importance of recognizing the combined features that can be seen in this rare, potentially malignant, entity.
SN - 1066-8969
SN - 1940-2465
ER -