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Peer-reviewedCC BY-NC-NDBMC medical imaging

Brain white matter functional alterations in patients with Alzheimer's disease and amnestic mild cognitive impairment.

  • Yi Lin1,2
  • Fengyi Dai1,3
  • Diewen Dong1,2
  • Yifan Jia4
  • Junqin Zhang5
  • Yan Chen6
  • Xiuhong Ge2
  • Zhongxiang Ding2
  • Luoyu Wang7
  • Qi Feng8
8 affiliations
  1. 1The Fourth Clinical College, Zhejiang Chinese Medical University, Hangzhou, P.R. China.
  2. 2Department of Radiology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, No. 261, Huansha Road, Shangcheng District, Hangzhou, P.R. China.
  3. 3Department of Radiology, Tonglu County Second People's Hospital, Hangzhou, P. R. China.
  4. 4School of Biomedical Engineering, ShanghaiTech University, Shanghai, P.R. China.
  5. 5First People's Hospital of Linping District, Hangzhou, China.
  6. 6Department of Psychiatry, Zhejiang Provincial People's Hospital/ People's Hospital of Hangzhou Medical College, Hangzhou, P.R. China.
  7. 7Department of Radiology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, No. 261, Huansha Road, Shangcheng District, Hangzhou, P.R. China. [email protected].
  8. 8Department of Radiology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, No. 261, Huansha Road, Shangcheng District, Hangzhou, P.R. China. [email protected].
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Abstract

Objectives

White matter (WM) blood oxygenation level-dependent (BOLD) signals show abnormalities in Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). However, the changes of WM static amplitude of low‑frequency fluctuation (sALFF) and dynamic amplitude of low‑frequency fluctuation (dALFF) as well as the WM seed-based functional connectivity (SBFC) remain to be further investigated.Methods

We compared WM sALFF, dALFF, and SBFC across 48 AD patients, 38 aMCI patients, and 38 healthy controls (HCs), with four covariates regressed out: age, gender, educational level, and head motion parameters (mean framewise displacement). The correlation between sALFF and dALFF values and cognitive performance in AD and aMCI groups was analyzed separately after regressing out the same four covariates, with FDR correction.Results

In AD and aMCI patients, the brain regions where WM sALFF and dALFF were abnormal in the right anterior thalamic radiation (ATR) and left ATR, respectively (sALFF: F = 10.171, P < 0.001; dALFF: F = 10.058, P < 0.001). In the right ATR-based functional connectivity (FC), the left putamen and right superior occipital gyrus showed abnormalities, while in the left ATR-based FC, the left middle frontal gyrus showed abnormality (left putamen: F = 10.201, P < 0.001; right superior occipital gyrus: F = 10.970, P < 0.001; left middle frontal gyrus: F = 10.933, P < 0.001). In addition, there was a significant negative correlation between sALFF value of right ATR and dALFF value of left ATR and overall cognitive performance (Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA)).Conclusion

This study provides novel neuroimaging evidence for AD pathogenesis and a broader biomarker of cognitive vulnerability or white matter functional dysregulation.

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Cite

BibTeXRIS
BibTeX
@article{lin2026brain,
  title = {{Brain white matter functional alterations in patients with Alzheimer's disease and amnestic mild cognitive impairment.}},
  author = {Yi Lin and Fengyi Dai and Diewen Dong and Yifan Jia and Junqin Zhang and Yan Chen and Xiuhong Ge and Zhongxiang Ding and Luoyu Wang and Qi Feng},
  journal = {BMC medical imaging},
  year = {2026},
  month = aug,
  doi = {10.1186/s12880-026-02653-0},
  url = {https://europepmc.org/article/MED/42972292},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Brain white matter functional alterations in patients with Alzheimer's disease and amnestic mild cognitive impairment.
AU  - Yi Lin
AU  - Fengyi Dai
AU  - Diewen Dong
AU  - Yifan Jia
AU  - Junqin Zhang
AU  - Yan Chen
AU  - Xiuhong Ge
AU  - Zhongxiang Ding
AU  - Luoyu Wang
AU  - Qi Feng
PY  - 2026
DA  - 2026/08/05
JO  - BMC medical imaging
DO  - 10.1186/s12880-026-02653-0
UR  - https://europepmc.org/article/MED/42972292
AB  - Objectives  White matter (WM) blood oxygenation level-dependent (BOLD) signals show abnormalities in Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). However, the changes of WM static amplitude of low‑frequency fluctuation (sALFF) and dynamic amplitude of low‑frequency fluctuation (dALFF) as well as the WM seed-based functional connectivity (SBFC) remain to be further investigated.Methods  We compared WM sALFF, dALFF, and SBFC across 48 AD patients, 38 aMCI patients, and 38 healthy controls (HCs), with four covariates regressed out: age, gender, educational level, and head motion parameters (mean framewise displacement). The correlation between sALFF and dALFF values and cognitive performance in AD and aMCI groups was analyzed separately after regressing out the same four covariates, with FDR correction.Results  In AD and aMCI patients, the brain regions where WM sALFF and dALFF were abnormal in the right anterior thalamic radiation (ATR) and left ATR, respectively (sALFF: F = 10.171, P < 0.001; dALFF: F = 10.058, P < 0.001). In the right ATR-based functional connectivity (FC), the left putamen and right superior occipital gyrus showed abnormalities, while in the left ATR-based FC, the left middle frontal gyrus showed abnormality (left putamen: F = 10.201, P < 0.001; right superior occipital gyrus: F = 10.970, P < 0.001; left middle frontal gyrus: F = 10.933, P < 0.001). In addition, there was a significant negative correlation between sALFF value of right ATR and dALFF value of left ATR and overall cognitive performance (Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA)).Conclusion  This study provides novel neuroimaging evidence for AD pathogenesis and a broader biomarker of cognitive vulnerability or white matter functional dysregulation.
SN  - 1471-2342
ER  -