Localized Tracheobronchial Transthyretin Amyloidosis Diagnosed After Hemoptysis: A Case Report
- 1Department of Respiratory Medicine Steel Memorial Muroran Hospital Muroran Japan
Abstract
Pulmonary involvement in transthyretin amyloidosis (ATTR) is rare, and tracheobronchial involvement is particularly uncommon. We report a case of wild‐type ATTR amyloidosis presenting with hemoptysis in a 66‐year‐old woman with dyspnea. Chest computed tomography revealed bronchial wall thickening and infiltrative opacities. Bronchoscopy showed irregular mucosal lesions extending from the trachea to both bronchi. Histopathological examination of bronchial biopsy specimens showed Congo red‐positive deposits, and immunohistochemistry confirmed transthyretin, establishing the diagnosis of ATTR amyloidosis. Systemic evaluation and genetic testing excluded systemic and hereditary disease, leading to a diagnosis of localized wild‐type ATTR. Bronchial aspirate cultures yielded Aspergillus fumigatus and Mycobacterium mucogenicum, and antifungal therapy was administered for a suspected concomitant airway infection. This rare presentation of tracheobronchial‐localized ATTR amyloidosis underscores the importance of considering amyloidosis in the differential diagnosis of hemoptysis and the diagnostic role of bronchoscopy.
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BibTeX
@article{inoue2026localized,
title = {{Localized Tracheobronchial Transthyretin Amyloidosis Diagnosed After Hemoptysis: A Case Report}},
author = {Koichi Inoue and Yasumasa Tanaka and Masahiro Yanagi and Haruhiko Michimata and Yuta Nagahisa and Shun Kondoh},
journal = {Respirology Case Reports},
year = {2026},
month = oct,
doi = {10.1002/rcr2.70781},
url = {https://doi.org/10.1002/rcr2.70781},
note = {CC BY},
}
RIS
TY - JOUR
TI - Localized Tracheobronchial Transthyretin Amyloidosis Diagnosed After Hemoptysis: A Case Report
AU - Koichi Inoue
AU - Yasumasa Tanaka
AU - Masahiro Yanagi
AU - Haruhiko Michimata
AU - Yuta Nagahisa
AU - Shun Kondoh
PY - 2026
DA - 2026/10/28
JO - Respirology Case Reports
DO - 10.1002/rcr2.70781
UR - https://doi.org/10.1002/rcr2.70781
AB - Pulmonary involvement in transthyretin amyloidosis (ATTR) is rare, and tracheobronchial involvement is particularly uncommon. We report a case of wild‐type ATTR amyloidosis presenting with hemoptysis in a 66‐year‐old woman with dyspnea. Chest computed tomography revealed bronchial wall thickening and infiltrative opacities. Bronchoscopy showed irregular mucosal lesions extending from the trachea to both bronchi. Histopathological examination of bronchial biopsy specimens showed Congo red‐positive deposits, and immunohistochemistry confirmed transthyretin, establishing the diagnosis of ATTR amyloidosis. Systemic evaluation and genetic testing excluded systemic and hereditary disease, leading to a diagnosis of localized wild‐type ATTR. Bronchial aspirate cultures yielded Aspergillus fumigatus and Mycobacterium mucogenicum, and antifungal therapy was administered for a suspected concomitant airway infection. This rare presentation of tracheobronchial‐localized ATTR amyloidosis underscores the importance of considering amyloidosis in the differential diagnosis of hemoptysis and the diagnostic role of bronchoscopy.
SN - 2051-3380
ER -