Preserving spiking and EEG in detailed models of human cortical microcircuits with morphological reductions
- 1Centre for Addiction and Mental Health
Abstract
Biophysically detailed models of human cortical microcircuit provide key insights into brain function and disease biomarkers, yet their computational cost lengthens simulation runtime and limits scalability. To address this, we systematically evaluated recent simplification methods for morphological reduction and synapse merging in terms of preserving spiking and electroencephalographic (EEG) properties of human cortical microcircuit models. At the single- cell level, reduced compartmental models accurately reproduced spiking behaviors. However, at the microcircuit level, while achieving a 5-fold speed-up, morphological reduction failed to preserve spectral dynamics of spiking and EEG despite maintaining average baseline and response firing rates. Conversely, applying synapse merging alone on the full morphology successfully reproduced both spiking activity and EEG dynamics, when constrained to [≤] 50 m spatial intervals, and yielded a 2-fold speed-up. These results were consistent across both cortical layer 2/3 and layer 5 models, and in depression models with reduced somatostatin interneuron inhibition. Our study identifies model simplification methods that speed up cortical microcircuit simulations while preserving the accuracy of the simulated brain signals.
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BibTeX
@misc{guetmccreight2026preserving,
title = {{Preserving spiking and EEG in detailed models of human cortical microcircuits with morphological reductions}},
author = {A. Guet-McCreight and E. Hay},
howpublished = {bioRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.18.752744},
url = {https://www.biorxiv.org/content/10.64898/2026.09.18.752744v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Preserving spiking and EEG in detailed models of human cortical microcircuits with morphological reductions
AU - A. Guet-McCreight
AU - E. Hay
PY - 2026
DA - 2026/09/18
PB - bioRxiv
DO - 10.64898/2026.09.18.752744
UR - https://www.biorxiv.org/content/10.64898/2026.09.18.752744v1
AB - Biophysically detailed models of human cortical microcircuit provide key insights into brain function and disease biomarkers, yet their computational cost lengthens simulation runtime and limits scalability. To address this, we systematically evaluated recent simplification methods for morphological reduction and synapse merging in terms of preserving spiking and electroencephalographic (EEG) properties of human cortical microcircuit models. At the single- cell level, reduced compartmental models accurately reproduced spiking behaviors. However, at the microcircuit level, while achieving a 5-fold speed-up, morphological reduction failed to preserve spectral dynamics of spiking and EEG despite maintaining average baseline and response firing rates. Conversely, applying synapse merging alone on the full morphology successfully reproduced both spiking activity and EEG dynamics, when constrained to [≤] 50 m spatial intervals, and yielded a 2-fold speed-up. These results were consistent across both cortical layer 2/3 and layer 5 models, and in depression models with reduced somatostatin interneuron inhibition. Our study identifies model simplification methods that speed up cortical microcircuit simulations while preserving the accuracy of the simulated brain signals.
ER -