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Peer-reviewedCC BY-NC 4.0Journal of Neurogastroenterology and Motility

Gut–Brain Axis-Mediated Neurological Manifestations in Inflammatory Bowel Disease: Mechanisms and Disease Spectrum

  • Bingchan Sun1,2
  • Guoxin Wang2,3
  • Xiaoxia Li4
  • Huimin Liu2
  • Huan Xv2
  • Qifang Wu2
  • Hongtao Li2
  • Xiangrong Ye2
  • Xijin Wang2
  • Mingfu Tong2,5
5 affiliations
  1. 1School of Health Science and Engineering, University of Shanghai for Science and Technology Shanghai China
  2. 2Department of Gastroenterology, Affiliated Hospital of Jiujiang University, Jiujiang Jiangxi China
  3. 3The First Clinical College of Gannan Medical University, Ganzhou Jiangxi China
  4. 4School of Basic Medicine, Jiujiang University, Jiujiang Jiangxi China
  5. 5Institute of Digestive Diseases, Jiujiang University, Jiujiang Jiangxi China
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Abstract

Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder of the gastrointestinal tract that is frequently associated with neuropsychiatric comorbidities, such as anxiety, depression, and other neurological disorders. Accumulating evidence suggests that these neuropsychiatric disorders are secondary conditions caused by impaired gut-brain communication. The gut–brain axis connects the gut and the brain via neural, endocrine, and immune signaling pathways, disruption of which is usually caused by intestinal microbiota imbalance, intestinal barrier damage, neuroinflammation and immune activation, and neuroendocrine pathway abnormalities. These pathways constitute the pathological basis of the disease spectrum of neuropsychiatric comorbidities in IBD patients. This article comprehensively reviews the core mechanisms and disease spectrum of gut–brain axis-mediated neurological and mental complications in IBD, and discusses potential therapeutic strategies and challenges.

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Cite

BibTeXRIS
BibTeX
@article{sun2026gutbrain,
  title = {{Gut–Brain Axis-Mediated Neurological Manifestations in Inflammatory Bowel Disease: Mechanisms and Disease Spectrum}},
  author = {Bingchan Sun and Guoxin Wang and Xiaoxia Li and Huimin Liu and Huan Xv and Qifang Wu and Hongtao Li and Xiangrong Ye and Xijin Wang and Mingfu Tong},
  journal = {Journal of Neurogastroenterology and Motility},
  year = {2026},
  month = oct,
  doi = {10.5056/jnm25167},
  url = {https://doi.org/10.5056/jnm25167},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Gut–Brain Axis-Mediated Neurological Manifestations in Inflammatory Bowel Disease: Mechanisms and Disease Spectrum
AU  - Bingchan Sun
AU  - Guoxin Wang
AU  - Xiaoxia Li
AU  - Huimin Liu
AU  - Huan Xv
AU  - Qifang Wu
AU  - Hongtao Li
AU  - Xiangrong Ye
AU  - Xijin Wang
AU  - Mingfu Tong
PY  - 2026
DA  - 2026/10/31
JO  - Journal of Neurogastroenterology and Motility
DO  - 10.5056/jnm25167
UR  - https://doi.org/10.5056/jnm25167
AB  - Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder of the gastrointestinal tract that is frequently associated with neuropsychiatric comorbidities, such as anxiety, depression, and other neurological disorders. Accumulating evidence suggests that these neuropsychiatric disorders are secondary conditions caused by impaired gut-brain communication. The gut–brain axis connects the gut and the brain via neural, endocrine, and immune signaling pathways, disruption of which is usually caused by intestinal microbiota imbalance, intestinal barrier damage, neuroinflammation and immune activation, and neuroendocrine pathway abnormalities. These pathways constitute the pathological basis of the disease spectrum of neuropsychiatric comorbidities in IBD patients. This article comprehensively reviews the core mechanisms and disease spectrum of gut–brain axis-mediated neurological and mental complications in IBD, and discusses potential therapeutic strategies and challenges.
SN  - 2093-0879
SN  - 2093-0887
ER  -