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Peer-reviewedCC BY 4.0Endocrinology, Diabetes & Metabolism

Association Between Amino Acid Levels and Thyroid Function Among Iranian Adults: A Cross‐Sectional Analysis of Bushehr Elderly Health (BEH) Program

  • Mohamad Mehdi Khadembashiri1
  • Kazem Khalagi2,3
  • Shahrzad Mohseni4
  • Alireza Amanollahi5
  • Fatemeh Bandarian1
  • Noushin Fahimfar2,6
  • Iraj Nabipour7
  • Mahnaz Pejman Sani4,8
  • Farideh Razi1
8 affiliations
  1. 1Metabolomics and Genomics Research Center Endocrinology and Metabolism Molecular‐Cellular Sciences Institute, Tehran University of Medical Sciences Tehran Iran
  2. 2Osteoporosis Research Center Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences Tehran Iran
  3. 3Obesity and Eating Habits Research Center Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences Tehran Iran
  4. 4Endocrinology and Metabolism Research Center Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences Tehran Iran
  5. 5Trauma and Injury Research Center Iran University of Medical Sciences Tehran Iran
  6. 6Department of Epidemiology and Biostatistics, School of Public Health Tehran University of Medical Sciences Tehran Iran
  7. 7The Persian Gulf Marine Biotechnology Research Center The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences Bushehr Iran
  8. 8Department of Endocrinology, Shariati Hospital, School of Medicine Tehran University of Medical Sciences Tehran Iran
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Abstract

Introduction: Thyroid hormones regulate key metabolic processes; however, the association between thyroid function and amino acid metabolism varies across studies. This study aimed to investigate the relationship between thyroid biomarkers and circulating amino acid concentrations in adults aged 50 years and older.

Methods: We initially enrolled a random subsample of 824 adults aged 50 years and older from the second recruitment of the Bushehr Elderly Health (BEH) Program. Because the clinical and subclinical hyperthyroidism groups were very small, 14 participants from these groups were excluded from the primary between‐group and regression analyses. Therefore, the primary analytical sample comprised 810 participants with euthyroid status, subclinical hypothyroidism, or clinical hypothyroidism. Associations between amino acid concentrations and thyroid biomarkers were assessed using multivariable linear regression models.

Results: The initial sample included 335 men and 489 women, with mean ages of 62.27 ± 8.57 and 61.47 ± 7.52 years, respectively. Although several nominal associations were observed between amino acids and TSH in crude or adjusted analyses, none remained statistically significant after false discovery rate (FDR) correction. No statistically significant differences in amino acid concentrations were observed between the thyroid disorder groups after FDR correction.

Conclusion: No statistically significant associations between amino acid concentrations and thyroid biomarkers remained after correction for multiple comparisons. Likewise, no significant differences in amino acid concentrations were observed between the examined thyroid disorder groups after FDR correction. Larger longitudinal studies are needed to determine whether the nominal findings observed in the present study are reproducible and biologically meaningful.

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Cite

BibTeXRIS
BibTeX
@article{khadembashiri2026association,
  title = {{Association Between Amino Acid Levels and Thyroid Function Among Iranian Adults: A Cross‐Sectional Analysis of Bushehr Elderly Health (BEH) Program}},
  author = {Mohamad Mehdi Khadembashiri and Kazem Khalagi and Shahrzad Mohseni and Alireza Amanollahi and Fatemeh Bandarian and Noushin Fahimfar and Iraj Nabipour and Mahnaz Pejman Sani and Farideh Razi},
  journal = {Endocrinology, Diabetes \& Metabolism},
  year = {2026},
  month = nov,
  doi = {10.1002/edm2.70375},
  url = {https://doi.org/10.1002/edm2.70375},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Association Between Amino Acid Levels and Thyroid Function Among Iranian Adults: A Cross‐Sectional Analysis of Bushehr Elderly Health (BEH) Program
AU  - Mohamad Mehdi Khadembashiri
AU  - Kazem Khalagi
AU  - Shahrzad Mohseni
AU  - Alireza Amanollahi
AU  - Fatemeh Bandarian
AU  - Noushin Fahimfar
AU  - Iraj Nabipour
AU  - Mahnaz Pejman Sani
AU  - Farideh Razi
PY  - 2026
DA  - 2026/11/03
JO  - Endocrinology, Diabetes & Metabolism
DO  - 10.1002/edm2.70375
UR  - https://doi.org/10.1002/edm2.70375
AB  - Introduction: Thyroid hormones regulate key metabolic processes; however, the association between thyroid function and amino acid metabolism varies across studies. This study aimed to investigate the relationship between thyroid biomarkers and circulating amino acid concentrations in adults aged 50 years and older.  Methods: We initially enrolled a random subsample of 824 adults aged 50 years and older from the second recruitment of the Bushehr Elderly Health (BEH) Program. Because the clinical and subclinical hyperthyroidism groups were very small, 14 participants from these groups were excluded from the primary between‐group and regression analyses. Therefore, the primary analytical sample comprised 810 participants with euthyroid status, subclinical hypothyroidism, or clinical hypothyroidism. Associations between amino acid concentrations and thyroid biomarkers were assessed using multivariable linear regression models.  Results: The initial sample included 335 men and 489 women, with mean ages of 62.27 ± 8.57 and 61.47 ± 7.52 years, respectively. Although several nominal associations were observed between amino acids and TSH in crude or adjusted analyses, none remained statistically significant after false discovery rate (FDR) correction. No statistically significant differences in amino acid concentrations were observed between the thyroid disorder groups after FDR correction.  Conclusion: No statistically significant associations between amino acid concentrations and thyroid biomarkers remained after correction for multiple comparisons. Likewise, no significant differences in amino acid concentrations were observed between the examined thyroid disorder groups after FDR correction. Larger longitudinal studies are needed to determine whether the nominal findings observed in the present study are reproducible and biologically meaningful.
SN  - 2398-9238
ER  -