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PreprintCC BY-NCbioRxiv

Measuring excitation/inhibition balance through field potentials

  • J. Rodriguez-Sanchez1
  • G. W. Diehl
  • P. J. Cunningham
  • D. Pinotsis
  • R. A. Adams
  • A. D. Redish
  1. 1University College London
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Abstract

Several electroencephalography-based metrics have been proposed to index excitation/inhibition balance (E/I). We used single-unit and local field potential recordings from rat medial prefrontal and orbitofrontal cortex and mouse visual cortex and hippocampus to evaluate four candidate metrics against empirically-measured E/I. While 1/f slope and gamma oscillations showed region and context dependencies, broadband (6-80 Hz) and high gamma (80-150 Hz) power consistently correlated with E/I, supporting their use as proxy measures. If at least 30 minutes' data from medial prefrontal cortex were used per animal, broadband power could rank the animals by their E/I ratio, suggesting it could be used as an individual differences measure.

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Cite

BibTeXRIS
BibTeX
@misc{rodriguezsanchez2026measuring,
  title = {{Measuring excitation/inhibition balance through field potentials}},
  author = {J. Rodriguez-Sanchez and G. W. Diehl and P. J. Cunningham and D. Pinotsis and R. A. Adams and A. D. Redish},
  howpublished = {bioRxiv},
  year = {2026},
  month = jul,
  doi = {10.64898/2026.07.16.738654},
  url = {https://www.biorxiv.org/content/10.64898/2026.07.16.738654v2},
  note = {CC BY-NC},
}
RIS
TY  - UNPB
TI  - Measuring excitation/inhibition balance through field potentials
AU  - J. Rodriguez-Sanchez
AU  - G. W. Diehl
AU  - P. J. Cunningham
AU  - D. Pinotsis
AU  - R. A. Adams
AU  - A. D. Redish
PY  - 2026
DA  - 2026/07/16
PB  - bioRxiv
DO  - 10.64898/2026.07.16.738654
UR  - https://www.biorxiv.org/content/10.64898/2026.07.16.738654v2
AB  - Several electroencephalography-based metrics have been proposed to index excitation/inhibition balance (E/I). We used single-unit and local field potential recordings from rat medial prefrontal and orbitofrontal cortex and mouse visual cortex and hippocampus to evaluate four candidate metrics against empirically-measured E/I. While 1/f slope and gamma oscillations showed region and context dependencies, broadband (6-80 Hz) and high gamma (80-150 Hz) power consistently correlated with E/I, supporting their use as proxy measures. If at least 30 minutes' data from medial prefrontal cortex were used per animal, broadband power could rank the animals by their E/I ratio, suggesting it could be used as an individual differences measure.
ER  -