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Peer-reviewedCC BY-NC 4.0BMB Reports

PPP1R3C functions as a tumor suppressor in endometrial cancer through promotion of glycogen synthesis

  • Hyang Sook Seol1,2
  • Jaewon Kim1,2
  • Ju Hee Oh3
  • Eunhye Choi3
  • Sanghyuk Lee1,2
  • Eun Ji Nam3
  • Jaesang Kim1,2
  1. 1Department of Life Science, Ewha Womans University, Seoul 03760, Institute of Women
  2. 2Ewha Research Center for Systems Biology, Ewha Womans University, Seoul 03760, Institute of Women
  3. 3Department of Obstetrics and Gynecology, Institute of Women
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Abstract

In this study, we report a novel function of protein phosphatase 1 regulatory subunit 3C (PPP1R3C)—which is known to promote glycogenesis by activating glycogen synthase and to inhibit glycogen breakdown by suppressing glycogen phosphorylase—as a tumor suppressor in endometrial cancer. First, the expression of PPP1R3C was strongly down-regulated in uterine corpus endometrial cancer (UCEC) tissues, and ectopic expression of PPP1R3C led to cell cycle arrest and apoptosis in HEC1A and HEC1B cells derived from UCEC. PPP1R3C also inhibited the growth of xenograft tumors in BALB/c nude mice. We found evidence indicating that the activation of glycogen synthesis was at least partly responsible for the tumor suppressor activity of PPP1R3C. Specifically, inhibition of glycogen synthase abrogated the effect of ectopic PPP1R3C expression on the growth inhibition of UCEC cells. Collectively, our data indicate that PPP1R3C is a tumor suppressor gene functioning through the induction of glycogen synthesis.

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Cite

BibTeXRIS
BibTeX
@article{seol2026ppp1r3c,
  title = {{PPP1R3C functions as a tumor suppressor in endometrial cancer through promotion of glycogen synthesis}},
  author = {Hyang Sook Seol and Jaewon Kim and Ju Hee Oh and Eunhye Choi and Sanghyuk Lee and Eun Ji Nam and Jaesang Kim},
  journal = {BMB Reports},
  year = {2026},
  month = oct,
  doi = {10.5483/bmbrep.2025-0134},
  url = {https://doi.org/10.5483/bmbrep.2025-0134},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - PPP1R3C functions as a tumor suppressor in endometrial cancer through promotion of glycogen synthesis
AU  - Hyang Sook Seol
AU  - Jaewon Kim
AU  - Ju Hee Oh
AU  - Eunhye Choi
AU  - Sanghyuk Lee
AU  - Eun Ji Nam
AU  - Jaesang Kim
PY  - 2026
DA  - 2026/10/31
JO  - BMB Reports
DO  - 10.5483/bmbrep.2025-0134
UR  - https://doi.org/10.5483/bmbrep.2025-0134
AB  - In this study, we report a novel function of protein phosphatase 1 regulatory subunit 3C (PPP1R3C)—which is known to promote glycogenesis by activating glycogen synthase and to inhibit glycogen breakdown by suppressing glycogen phosphorylase—as a tumor suppressor in endometrial cancer. First, the expression of PPP1R3C was strongly down-regulated in uterine corpus endometrial cancer (UCEC) tissues, and ectopic expression of PPP1R3C led to cell cycle arrest and apoptosis in HEC1A and HEC1B cells derived from UCEC. PPP1R3C also inhibited the growth of xenograft tumors in BALB/c nude mice. We found evidence indicating that the activation of glycogen synthesis was at least partly responsible for the tumor suppressor activity of PPP1R3C. Specifically, inhibition of glycogen synthase abrogated the effect of ectopic PPP1R3C expression on the growth inhibition of UCEC cells. Collectively, our data indicate that PPP1R3C is a tumor suppressor gene functioning through the induction of glycogen synthesis.
SN  - 1976-6696
SN  - 1976-670X
ER  -