Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 23 min ago
Peer-reviewedCC BY 4.0JACC: Advances

Moderate-to-Vigorous Intensity Physical Activity and Risk of Incident Atrial Fibrillation in Atrial Cardiomyopathy

  • Min Kim1
  • Pil-Sung Yang2
  • Ho-Gi Chung3
  • Juntae Kim4
  • Daehoon Kim3
  • Han-Joon Bae5
  • Moon-Hyun Kim6
  • Boyoung Joung3
6 affiliations
  1. 1Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  2. 2Division of Cardiology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea
  3. 3Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
  4. 4Division of Cardiology, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea
  5. 5Division of Cardiology, Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Republic of Korea
  6. 6Division of Cardiology, Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Republic of Korea
Read full textDOICite

Abstract

Background: Current guidelines recommend physical activity for atrial fibrillation (AF) prevention, yet its role in individuals with atrial cardiomyopathy (AtCM) remains unclear.

Objectives: We investigated the association between accelerometer-measured moderate-to-vigorous intensity physical activity (MVPA) and incident AF according to AtCM status.

Methods: Among 10,003 UK Biobank participants, AtCM was identified via multimodal approach integrating cardiovascular magnetic resonance imaging and 12-lead electrocardiography. Multivariable adjusted Cox proportional hazards models assessed the association between 7-day accelerometer-measured MVPA and incident AF. An interaction term evaluated substrate-specific associations.

Results: AtCM was identified in 4.5% of participants. Over a median follow-up of 3.2 years, AtCM was associated with an increased risk of AF (HR: 3.01; 95% CI: 1.69 to 5.37). AtCM status significantly modified the MVPA-AF association (P for interaction = 0.029). Without AtCM, MVPA showed marginal risk reduction (HR per 10-minute increase: 0.94; 95% CI: 0.87-1.01). Conversely, with AtCM, MVPA was strongly associated with a lower AF risk (HR per 10-minute increase: 0.76; 95% CI: 0.62-0.93). The absolute risk reduction was 2.82 AF events per 1,000 person-years for every 10-minute increase in MVPA in the AtCM group, significantly greater than without AtCM (difference: −2.66; 95% CI: -4.32 to −0.73; P = 0.011). Findings remained robust across comprehensive sensitivity analyses.

Conclusions: MVPA demonstrated a robust inverse association with incident AF risk, particularly in individuals with AtCM. Identifying subclinical atrial substrate may guide targeted physical activity recommendations, suggesting MVPA as a potent lifestyle intervention to attenuate the transition from subclinical remodeling to overt clinical arrhythmia.

Related

  1. Accelerometer-derived moderate-to-vigorous-intensity physical activity: sex differences in health benefits and health equivalence between the sexes: a prospective cohort study
    Zihao Zheng, Haoyu Liu, Xiaoxuan Ge +7
    Frontiers in Public HealthPeer-reviewedCC BY 4.0Full textPhysiologyCrossref
  2. Germany’s youth city versus rural dwellers engage in more moderate-to-vigorous physical activity
    Markus Reichert, Carina Nigg, Janis Fiedler +10
    Scientific ReportsPeer-reviewedCC BYFull textPhysiologyDOAJ
  3. Effectiveness of mobile health interventions for promoting moderate-to-vigorous physical activity in children and adolescents: systematic review and meta-analysis.
    Binping Gong, Da Wang, Xinyu Chen +2
    BMC public healthPeer-reviewedCC BY-NC-NDFull textEpidemiology & public healthEurope PMCPMCDOAJ
  4. Moderate-to-vigorous physical activity, age-dependent adiposity, and obesity risk in older adults at high cardiovascular risk
    E. Fornara, M. H. Hernandez, A. Goday +15
    medRxivPreprintCC BY-NC-NDFull textEpidemiology & public healthmedRxiv
  5. Changes in the frequency of vigorous physical activity across four survey cycles: analyses of 12-year repeated cross-sectional surveys of 729,201 adolescents
    Zhengyang Yang, Lubo Zhai, Jin Yan
    BMC Public HealthPeer-reviewedCC BY 4.0Epidemiology & public healthCrossref

Cite

BibTeXRIS
BibTeX
@article{kim2026moderatetovigorous,
  title = {{Moderate-to-Vigorous Intensity Physical Activity and Risk of Incident Atrial Fibrillation in Atrial Cardiomyopathy}},
  author = {Min Kim and Pil-Sung Yang and Ho-Gi Chung and Juntae Kim and Daehoon Kim and Han-Joon Bae and Moon-Hyun Kim and Boyoung Joung},
  journal = {JACC: Advances},
  year = {2026},
  month = aug,
  doi = {10.1016/j.jacadv.2026.102999},
  url = {https://doi.org/10.1016/j.jacadv.2026.102999},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Moderate-to-Vigorous Intensity Physical Activity and Risk of Incident Atrial Fibrillation in Atrial Cardiomyopathy
AU  - Min Kim
AU  - Pil-Sung Yang
AU  - Ho-Gi Chung
AU  - Juntae Kim
AU  - Daehoon Kim
AU  - Han-Joon Bae
AU  - Moon-Hyun Kim
AU  - Boyoung Joung
PY  - 2026
DA  - 2026/08/28
JO  - JACC: Advances
DO  - 10.1016/j.jacadv.2026.102999
UR  - https://doi.org/10.1016/j.jacadv.2026.102999
AB  - Background: Current guidelines recommend physical activity for atrial fibrillation (AF) prevention, yet its role in individuals with atrial cardiomyopathy (AtCM) remains unclear.  Objectives: We investigated the association between accelerometer-measured moderate-to-vigorous intensity physical activity (MVPA) and incident AF according to AtCM status.  Methods: Among 10,003 UK Biobank participants, AtCM was identified via multimodal approach integrating cardiovascular magnetic resonance imaging and 12-lead electrocardiography. Multivariable adjusted Cox proportional hazards models assessed the association between 7-day accelerometer-measured MVPA and incident AF. An interaction term evaluated substrate-specific associations.  Results: AtCM was identified in 4.5% of participants. Over a median follow-up of 3.2 years, AtCM was associated with an increased risk of AF (HR: 3.01; 95% CI: 1.69 to 5.37). AtCM status significantly modified the MVPA-AF association (P for interaction = 0.029). Without AtCM, MVPA showed marginal risk reduction (HR per 10-minute increase: 0.94; 95% CI: 0.87-1.01). Conversely, with AtCM, MVPA was strongly associated with a lower AF risk (HR per 10-minute increase: 0.76; 95% CI: 0.62-0.93). The absolute risk reduction was 2.82 AF events per 1,000 person-years for every 10-minute increase in MVPA in the AtCM group, significantly greater than without AtCM (difference: −2.66; 95% CI: -4.32 to −0.73; P = 0.011). Findings remained robust across comprehensive sensitivity analyses.  Conclusions: MVPA demonstrated a robust inverse association with incident AF risk, particularly in individuals with AtCM. Identifying subclinical atrial substrate may guide targeted physical activity recommendations, suggesting MVPA as a potent lifestyle intervention to attenuate the transition from subclinical remodeling to overt clinical arrhythmia.
SN  - 2772-963X
ER  -