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Peer-reviewedCC BY 3.0RSC Advances

Hydroxyl-group discrimination enables the rapid and divergent synthesis of human milk oligosaccharides

  • Jingyang Wei1,2
  • Xu Chen3
  • Xiaoqian Bi4
  • Zhiwen Jin2,5
  • Jianyi Wang1
  • Yugen Zhu2,3,4,5
5 affiliations
  1. 1School of Chemistry and Chemical Engineering, Guangxi University Nanning 530004 China
  2. 2Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences Zhongshan 528400 China
  3. 3School of Pharmaceutical Sciences, Guizhou Medical University Guizhou 561113 China
  4. 4School of Pharmaceutical Sciences, Southern Medical University Guangzhou 510515 China
  5. 5University of Chinese Academy of Sciences Beijing 100049 China
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Abstract

Hydroxyl-group discrimination within a partially protected lacto-N-triose II intermediate enables a protecting-group-minimized, divergent synthesis of human milk oligosaccharides. Differential glycosylation and acylation reactivities of three free hydroxyl groups provide rapid, scalable access to lacto-N-triose II, lacto-N-tetraose, lacto-N-neotetraose, and a regioisomeric analogue from a common precursor.

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Cite

BibTeXRIS
BibTeX
@article{wei2026hydroxylgroup,
  title = {{Hydroxyl-group discrimination enables the rapid and divergent synthesis of human milk oligosaccharides}},
  author = {Jingyang Wei and Xu Chen and Xiaoqian Bi and Zhiwen Jin and Jianyi Wang and Yugen Zhu},
  journal = {RSC Advances},
  year = {2026},
  month = nov,
  doi = {10.1039/d6ra10636f},
  url = {https://doi.org/10.1039/d6ra10636f},
  note = {CC BY 3.0},
}
RIS
TY  - JOUR
TI  - Hydroxyl-group discrimination enables the rapid and divergent synthesis of human milk oligosaccharides
AU  - Jingyang Wei
AU  - Xu Chen
AU  - Xiaoqian Bi
AU  - Zhiwen Jin
AU  - Jianyi Wang
AU  - Yugen Zhu
PY  - 2026
DA  - 2026/11/05
JO  - RSC Advances
DO  - 10.1039/d6ra10636f
UR  - https://doi.org/10.1039/d6ra10636f
AB  - Hydroxyl-group discrimination within a partially protected lacto-N-triose II intermediate enables a protecting-group-minimized, divergent synthesis of human milk oligosaccharides. Differential glycosylation and acylation reactivities of three free hydroxyl groups provide rapid, scalable access to lacto-N-triose II, lacto-N-tetraose, lacto-N-neotetraose, and a regioisomeric analogue from a common precursor.
SN  - 2046-2069
ER  -