Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 1 h ago
Peer-reviewedCC BYIJU case reports

Primary Prostatic Diffuse Large B-Cell Lymphoma Mimicking Prostate Cancer With a Normal Prostate-Specific Antigen Level.

  • Kota Amamoto1
  • Yuichiro Nakamura1
  • Hajime Fukushima1
  • Junki Harada1
  • Tsuyoshi Matsuda1
  • Itsuho Ito1
  • Kensuke Mitsunari1
  • Tomohiro Matsuo1
  • Kojiro Ohba1
  • Ryoichi Imamura1
  1. 1Department of Urology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan.
Read full textPDFDOICite

Abstract

Introduction

Primary prostatic lymphoma is rare and may mimic prostate cancer clinically and radiologically.Case presentation

A 66-year-old man was referred for evaluation of suspected advanced prostate cancer. Despite a normal prostate-specific antigen level of 0.573 ng/mL, imaging revealed a prostatic mass with suspected bladder invasion and bilateral hydronephrosis. Prostate needle biopsy showed atypical lymphocytic infiltration but could not distinguish lymphoma from inflammatory changes. Additional transurethral biopsy provided sufficient tissue for histopathological and immunohistochemical evaluation, establishing a diagnosis of primary prostatic diffuse large B-cell lymphoma.Conclusion

Primary prostatic lymphoma should be considered when clinical and imaging findings suggest prostate cancer despite a normal prostate-specific antigen level. Additional tissue sampling should be considered when needle biopsy is inconclusive despite persistent clinical suspicion of lymphoma.

Related

  1. Case Report: Prostatic infarction mimicking prostate cancer in a patient with markedly elevated prostate-specific antigen
    Huajian Ye, Yaokang Chen, Liming Yu
    Frontiers in medicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC
  2. Gallium-68 (68Ga)-Labelled Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography in the Initial Staging of High-Risk Prostatic Adenocarcinoma: Reclassification to Oligometastatic Disease and Change in Treatment Intent
    Carlos Paul Villalba-Meneses, Adriana P Noboa, Veronica Marcela Villegas-Paredes
    CureusPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  3. Primary Tracheal Lymphoma Mimicking Asthma Exacerbation
    Keigo Uchimura, Sumitaka Kitajima, Makoto Hirai +1
    Respirology case reportsPeer-reviewedCC BYFull textGeneral medicineEurope PMCEurope PMCPMC
  4. Primary gastric tuberculosis mimicking gastric lymphoma: a case report and multimodality imaging findings.
    Zhengguo Wan, Yuanyuan Sun, Penghua Liu +1
    Frontiers in medicinePeer-reviewedCC BYFull textSurgery & anaesthesiaEurope PMC
  5. Holmium laser enucleation of the prostate for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia
    Niranjan Sathianathen, Eu Chang Hwang, Sarah Jane Brown +4
    The Cochrane Database of Systematic ReviewsPeer-reviewedPublisher termsFull textGeneral medicinePMC

Cite

BibTeXRIS
BibTeX
@article{amamoto2026primary,
  title = {{Primary Prostatic Diffuse Large B-Cell Lymphoma Mimicking Prostate Cancer With a Normal Prostate-Specific Antigen Level.}},
  author = {Kota Amamoto and Yuichiro Nakamura and Hajime Fukushima and Junki Harada and Tsuyoshi Matsuda and Itsuho Ito and Kensuke Mitsunari and Tomohiro Matsuo and Kojiro Ohba and Ryoichi Imamura},
  journal = {IJU case reports},
  year = {2026},
  month = oct,
  doi = {10.1002/iju5.70286},
  url = {https://europepmc.org/article/MED/42947983},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Primary Prostatic Diffuse Large B-Cell Lymphoma Mimicking Prostate Cancer With a Normal Prostate-Specific Antigen Level.
AU  - Kota Amamoto
AU  - Yuichiro Nakamura
AU  - Hajime Fukushima
AU  - Junki Harada
AU  - Tsuyoshi Matsuda
AU  - Itsuho Ito
AU  - Kensuke Mitsunari
AU  - Tomohiro Matsuo
AU  - Kojiro Ohba
AU  - Ryoichi Imamura
PY  - 2026
DA  - 2026/10/26
JO  - IJU case reports
DO  - 10.1002/iju5.70286
UR  - https://europepmc.org/article/MED/42947983
AB  - Introduction  Primary prostatic lymphoma is rare and may mimic prostate cancer clinically and radiologically.Case presentation  A 66-year-old man was referred for evaluation of suspected advanced prostate cancer. Despite a normal prostate-specific antigen level of 0.573 ng/mL, imaging revealed a prostatic mass with suspected bladder invasion and bilateral hydronephrosis. Prostate needle biopsy showed atypical lymphocytic infiltration but could not distinguish lymphoma from inflammatory changes. Additional transurethral biopsy provided sufficient tissue for histopathological and immunohistochemical evaluation, establishing a diagnosis of primary prostatic diffuse large B-cell lymphoma.Conclusion  Primary prostatic lymphoma should be considered when clinical and imaging findings suggest prostate cancer despite a normal prostate-specific antigen level. Additional tissue sampling should be considered when needle biopsy is inconclusive despite persistent clinical suspicion of lymphoma.
SN  - 2577-171X
ER  -