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Peer-reviewedCC BYActa neurochirurgica

Copenhagen longitudinal study on quality of life in a young adult population with gliomas.

  • Katrine Arnkjær1,2
  • Mette Bruun-Pedersen3,4
  • Esben Meulengracht Flachs5
  • Anne Norup6,7
  • Jane Skjøth-Rasmussen3,8,4
8 affiliations
  1. 1Department of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, Denmark. [email protected].
  2. 2Danish Comprehensive Cancer Center (DCCC), Network for Adolescents and Young Adults Cancer Research in Denmark (NAYAcare DK), Aarhus, Denmark. [email protected].
  3. 3Department of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, Denmark.
  4. 4Danish Comprehensive Cancer Center (DCCC), Network for Adolescents and Young Adults Cancer Research in Denmark (NAYAcare DK), Aarhus, Denmark.
  5. 5Occupational and Environmental Medicine, Copenhagen University Hospital, Bispebjerg Hospital, Copenhagen, Denmark.
  6. 6Neurorehabilitation Research and Knowledge Centre, Copenhagen University Hospital, Rigshospitalet, Denmark.
  7. 7Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark.
  8. 8Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
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Abstract

Background

Patients diagnosed with glioma in the brain are prone to lowered quality of life (QoL). The risk of neurological symptoms and emotional burden may restrict participation in everyday life.The glioma diagnosis is considered chronic with a limited overall survival rate, which is particularly concerning for adolescent and young adults (AYA).Methods

In a longitudinal and prospective study with consecutive inclusion, we followed the QoL in glioma patients aged 18-35 (n = 46). Assessment was conducted online with the self-report measures Functional Assessment of Cancer Treatment-Brain (FACT-Br) and Major Depression Inventory (MDI). The assessment was performed consecutively pre- and postoperatively four times per year.Results

On group level we found that the higher burden of pain, lack of energy and greater burden of seizures and decreased subjective cognitive functioning, significantly predicted the total level of QoL. Tumor grade, time since surgery, sex or number of neurosurgical interventions were not found to significant predict the overall QoL.Conclusion

The results underline the importance of optimizing the seizure control and treating pain sufficiently as well as assessing fatigue and cognitive functions. By routinely screening the patients with a standardized QoL-questionnaire, unmet needs can be clarified, and rehabilitation be optimized to prevent deterioration in QoL.

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Cite

BibTeXRIS
BibTeX
@article{arnkjær2026copenhagen,
  title = {{Copenhagen longitudinal study on quality of life in a young adult population with gliomas.}},
  author = {Katrine Arnkjær and Mette Bruun-Pedersen and Esben Meulengracht Flachs and Anne Norup and Jane Skjøth-Rasmussen},
  journal = {Acta neurochirurgica},
  year = {2026},
  month = sep,
  doi = {10.1007/s00701-026-07028-6},
  url = {https://europepmc.org/article/MED/42901970},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Copenhagen longitudinal study on quality of life in a young adult population with gliomas.
AU  - Katrine Arnkjær
AU  - Mette Bruun-Pedersen
AU  - Esben Meulengracht Flachs
AU  - Anne Norup
AU  - Jane Skjøth-Rasmussen
PY  - 2026
DA  - 2026/09/01
JO  - Acta neurochirurgica
DO  - 10.1007/s00701-026-07028-6
UR  - https://europepmc.org/article/MED/42901970
AB  - Background  Patients diagnosed with glioma in the brain are prone to lowered quality of life (QoL). The risk of neurological symptoms and emotional burden may restrict participation in everyday life.The glioma diagnosis is considered chronic with a limited overall survival rate, which is particularly concerning for adolescent and young adults (AYA).Methods  In a longitudinal and prospective study with consecutive inclusion, we followed the QoL in glioma patients aged 18-35 (n = 46). Assessment was conducted online with the self-report measures Functional Assessment of Cancer Treatment-Brain (FACT-Br) and Major Depression Inventory (MDI). The assessment was performed consecutively pre- and postoperatively four times per year.Results  On group level we found that the higher burden of pain, lack of energy and greater burden of seizures and decreased subjective cognitive functioning, significantly predicted the total level of QoL. Tumor grade, time since surgery, sex or number of neurosurgical interventions were not found to significant predict the overall QoL.Conclusion  The results underline the importance of optimizing the seizure control and treating pain sufficiently as well as assessing fatigue and cognitive functions. By routinely screening the patients with a standardized QoL-questionnaire, unmet needs can be clarified, and rehabilitation be optimized to prevent deterioration in QoL.
SN  - 0001-6268
SN  - 0942-0940
ER  -