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Peer-reviewedCC BY 4.0PLOS One

Clinical and ocular factors associated with visual field progression following optic disc haemorrhage in glaucoma

  • Haewon Lee1
  • Ji Eun Song1,2
  • Seong Ho Kim2
  • Byeong Seok Kim2
  • Yongwoo Lee3
  1. 1Kangwon National University School of Medicine, Chuncheon, Republic of Korea
  2. 2Department of Ophthalmology, Kangwon National University Hospital, Chuncheon, Republic of Korea
  3. 3Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea
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Abstract

Background: To investigate the structural and clinical factors linked to visual field (VF) progression in glaucomatous eyes after the initial detection of optic disc haemorrhage (DH) in patients with primary open-angle glaucoma (POAG). Methods: This study included 92 eyes of 92 patients who presented with at least one optic DH on stereoscopic optic disc and red-free photography. The included patients had a minimum follow-up of 3 years after initial detection of DH and at least 5 reliable standard automated perimetry investigations. VF progression was assessed using event-based guided progression analysis (GPA). Baseline demographic, clinical, and ocular parameters were examined using Cox proportional hazards regression to identify the independent predictors of functional deterioration. Results: Among the patients, 32 (34.8%) showed VF progression and 60 (65.2%) remained stable. In univariate analysis, recurrent DH, longer axial length, thinner central corneal thickness (CCT), and intraocular pressure (IOP) fluctuation were significantly associated with VF progression. In multivariate analysis, recurrent DH (HR 4.008, p < 0.001), longer axial length (HR 1.287, p = 0.005), thinner CCT (HR 0.865, p = 0.005), and greater IOP fluctuation (HR 1.997, p = 0.032) remained independently associated with VF progression. Conclusions: Recurrent DH, longer axial length, thinner CCT, and greater IOP fluctuation were independently associated with VF progression following optic DH. These factors may help identify glaucomatous eyes at higher risk of progression and support closer clinical monitoring after the initial detection of DH.

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Cite

BibTeXRIS
BibTeX
@article{lee2026clinical,
  title = {{Clinical and ocular factors associated with visual field progression following optic disc haemorrhage in glaucoma}},
  author = {Haewon Lee and Ji Eun Song and Seong Ho Kim and Byeong Seok Kim and Yongwoo Lee},
  journal = {PLOS One},
  year = {2026},
  month = nov,
  doi = {10.1371/journal.pone.0361865},
  url = {https://doi.org/10.1371/journal.pone.0361865},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Clinical and ocular factors associated with visual field progression following optic disc haemorrhage in glaucoma
AU  - Haewon Lee
AU  - Ji Eun Song
AU  - Seong Ho Kim
AU  - Byeong Seok Kim
AU  - Yongwoo Lee
PY  - 2026
DA  - 2026/11/03
JO  - PLOS One
DO  - 10.1371/journal.pone.0361865
UR  - https://doi.org/10.1371/journal.pone.0361865
AB  - Background: To investigate the structural and clinical factors linked to visual field (VF) progression in glaucomatous eyes after the initial detection of optic disc haemorrhage (DH) in patients with primary open-angle glaucoma (POAG). Methods: This study included 92 eyes of 92 patients who presented with at least one optic DH on stereoscopic optic disc and red-free photography. The included patients had a minimum follow-up of 3 years after initial detection of DH and at least 5 reliable standard automated perimetry investigations. VF progression was assessed using event-based guided progression analysis (GPA). Baseline demographic, clinical, and ocular parameters were examined using Cox proportional hazards regression to identify the independent predictors of functional deterioration. Results: Among the patients, 32 (34.8%) showed VF progression and 60 (65.2%) remained stable. In univariate analysis, recurrent DH, longer axial length, thinner central corneal thickness (CCT), and intraocular pressure (IOP) fluctuation were significantly associated with VF progression. In multivariate analysis, recurrent DH (HR 4.008, p < 0.001), longer axial length (HR 1.287, p = 0.005), thinner CCT (HR 0.865, p = 0.005), and greater IOP fluctuation (HR 1.997, p = 0.032) remained independently associated with VF progression. Conclusions: Recurrent DH, longer axial length, thinner CCT, and greater IOP fluctuation were independently associated with VF progression following optic DH. These factors may help identify glaucomatous eyes at higher risk of progression and support closer clinical monitoring after the initial detection of DH.
SN  - 1932-6203
ER  -