Skip to content
DraconiticResearch
Search Sources API
184,937 studies31 sourcesUpdated 39 min ago
PreprintCC BY 4.0arXiv

Boundary inference for the Makeham term in mortality models

Abstract

Whether a mortality model needs a Makeham term, the constant representing background mortality, is commonly decided with a likelihood-ratio test. The constant cannot be negative, so testing its absence places it on a boundary, where the usual chi-squared calibration fails. Assuming independent Poisson death counts and standard regularity conditions, we show that when the constant is the only parameter on a boundary the statistic converges to an equal mixture of a point mass at zero and a chi-squared distribution with one degree of freedom: at the 5% level the critical value is 2.71, not 3.84. We state conditions under which the correction holds for Makeham models, verify them for Gompertz--Makeham and gamma-Gompertz--Makeham, and quantify the information about the constant, which fixes the local power, the smallest detectable term, and the loss of detectability as the age window narrows. When a gamma-frailty variance is estimated at a true value of zero, the limit is no longer a chi-squared mixture and the correction rejects too often. Monte Carlo experiments show the conventional cutoff rejecting at half the nominal level, a correctly calibrated test missing a term at its detection threshold in most samples, and excess rejections persisting as exposure grows.

Related

  1. BiNVaST: niche boundary-preserving and synthetic data-guided variational autoencoders for concordant inference across high-resolution spatial transcriptomic platforms
    J. Zhang, L. Li, L. Liu +6
    bioRxivPreprintCC BY-NC-NDFull textBioinformatics & computational biologybioRxiv
  2. Parameter non-identifiability limits ecological inference from historical plague mortality records
    N. W. Martin, N. Gauthier
    bioRxivPreprintCC BYFull textEcologybioRxiv
  3. Long-term mortality and late sequelae after bacterial meningitis: A matched cohort study with six decades of follow-up
    Pelle Trier Petersen, Niels Obel, Lars Haukali Omland +5
    Journal of InfectionPeer-reviewedCC BYFull textMicrobiologyDOAJ
  4. High‐Throughput Geocoding to Assess Short‐Term Air Pollution in Correlation With Mortality in a French Cancer Patient Cohort
    Loice Pokam, Joséphine Bocquet, Nadia Hégarat +10
    International Journal of CancerPeer-reviewedCC BY 4.0Full textGeneral biologyEpidemiology & public healthHAL
  5. Correcting for ascertainment bias in the inference of population structure
    Gilles Guillot, Matthieu Foll
    BioinformaticsPeer-reviewedLicence not statedFull text34 citedGenetics & genomicsHAL
BibTeX
@misc{patricio2026boundary,
  title = {{Boundary inference for the Makeham term in mortality models}},
  author = {Silvio C. Patricio},
  howpublished = {arXiv},
  year = {2026},
  month = oct,
  doi = {10.48550/arxiv.2610.03685},
  eprint = {2610.03685},
  archivePrefix = {arXiv},
  url = {https://arxiv.org/abs/2610.03685},
  note = {CC BY 4.0},
}
RIS
TY  - UNPB
TI  - Boundary inference for the Makeham term in mortality models
AU  - Silvio C. Patricio
PY  - 2026
DA  - 2026/10/15
PB  - arXiv
DO  - 10.48550/arxiv.2610.03685
UR  - https://arxiv.org/abs/2610.03685
AB  - Whether a mortality model needs a Makeham term, the constant representing background mortality, is commonly decided with a likelihood-ratio test. The constant cannot be negative, so testing its absence places it on a boundary, where the usual chi-squared calibration fails. Assuming independent Poisson death counts and standard regularity conditions, we show that when the constant is the only parameter on a boundary the statistic converges to an equal mixture of a point mass at zero and a chi-squared distribution with one degree of freedom: at the 5% level the critical value is 2.71, not 3.84. We state conditions under which the correction holds for Makeham models, verify them for Gompertz--Makeham and gamma-Gompertz--Makeham, and quantify the information about the constant, which fixes the local power, the smallest detectable term, and the loss of detectability as the age window narrows. When a gamma-frailty variance is estimated at a true value of zero, the limit is no longer a chi-squared mixture and the correction rejects too often. Monte Carlo experiments show the conventional cutoff rejecting at half the nominal level, a correctly calibrated test missing a term at its detection threshold in most samples, and excess rejections persisting as exposure grows.
ER  -