Left Ventricular Volume and Function Assessment Using a Reduced-Slice Approach in Cardiovascular Magnetic Resonance
- 1Karolinska Institutet
Abstract
ObjectTo test the hypothesis that a reduced-slice geometric model can maintain left ventricular (LV) volumetry, thereby providing a rapid and reliable clinical alternative to conventional full-stack planimetry.
Materials and MethodsIn a retrospective cohort of 342 patients with full-stack cardiovascular magnetic resonance (CMR), nine geometric combinations (3, 4, or 5 short-axis (SAx) slices and a 2, 3, or 4 chambered long-axis (LAx) slice) were evaluated by decimating the original acquisitions. Volumes were calculated using trapezoidal mid-cavity approximations and a generalized prismoidal model for the basal region. This was compared to the full-stack reference using concordance correlation coefficient (CCC), repeated measures ANOVA, pairwise tests and Bayes factor log10(BF10) analysis.
ResultsThe choice of LAx view influenced the accuracy approximately 50 times more than SAx slice count. For a 2ch + 5 SAx protocol, EF bias was just 0.83% (LoA: -6.18 to 7.84%), with a minimum detectable change (MDC) of 7.01%, compared to 8.7% reported for expert human readers, suggesting strong concordance (CCC>0.90) with full-stack. Bayesian analysis decisively supported 5 over 3 SAx slices (log10(BF10) = 6.42).
ConclusionThis proposed model successfully minimizes scan time and breath-holds while maintaining clinical accuracy. Functional metric bias remains lower than scan-rescan variability.
Related
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BibTeX
@misc{tejaswi2026left,
title = {{Left Ventricular Volume and Function Assessment Using a Reduced-Slice Approach in Cardiovascular Magnetic Resonance}},
author = {A. Tejaswi and A. Fyrdahl and A. Sigfridsson},
howpublished = {medRxiv},
year = {2026},
month = may,
doi = {10.64898/2026.05.29.26354413},
url = {https://www.medrxiv.org/content/10.64898/2026.05.29.26354413v2},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Left Ventricular Volume and Function Assessment Using a Reduced-Slice Approach in Cardiovascular Magnetic Resonance
AU - A. Tejaswi
AU - A. Fyrdahl
AU - A. Sigfridsson
PY - 2026
DA - 2026/05/29
PB - medRxiv
DO - 10.64898/2026.05.29.26354413
UR - https://www.medrxiv.org/content/10.64898/2026.05.29.26354413v2
AB - ObjectTo test the hypothesis that a reduced-slice geometric model can maintain left ventricular (LV) volumetry, thereby providing a rapid and reliable clinical alternative to conventional full-stack planimetry. Materials and MethodsIn a retrospective cohort of 342 patients with full-stack cardiovascular magnetic resonance (CMR), nine geometric combinations (3, 4, or 5 short-axis (SAx) slices and a 2, 3, or 4 chambered long-axis (LAx) slice) were evaluated by decimating the original acquisitions. Volumes were calculated using trapezoidal mid-cavity approximations and a generalized prismoidal model for the basal region. This was compared to the full-stack reference using concordance correlation coefficient (CCC), repeated measures ANOVA, pairwise tests and Bayes factor log10(BF10) analysis. ResultsThe choice of LAx view influenced the accuracy approximately 50 times more than SAx slice count. For a 2ch + 5 SAx protocol, EF bias was just 0.83% (LoA: -6.18 to 7.84%), with a minimum detectable change (MDC) of 7.01%, compared to 8.7% reported for expert human readers, suggesting strong concordance (CCC>0.90) with full-stack. Bayesian analysis decisively supported 5 over 3 SAx slices (log10(BF10) = 6.42). ConclusionThis proposed model successfully minimizes scan time and breath-holds while maintaining clinical accuracy. Functional metric bias remains lower than scan-rescan variability.
ER -