Plant autoinhibited Ca2+-ATPases: shaping calcium signals for growth, stress adaptation, and crop improvement
Abstract
P-type ATPases are conserved ATP-driven ion transporters that maintain cellular ion homeostasis. Plant P-type IIB Ca2+-ATPases, known as autoinhibited Ca2+-ATPases (ACAs), are key regulators of Ca2+ signaling networks. This review summarizes the structural features, Ca2+/calmodulin-dependent regulation, evolutionary diversification, and biological functions of plant ACAs. By contributing to cytosolic Ca2+ clearance and the restoration of basal Ca2+ levels, ACAs may modulate stimulus-specific Ca2+ dynamics and participate in diverse physiological processes, including plant growth, development, stomatal movement, immunity, and abiotic stress adaptation. Comparative analyses across plant species highlight functional specialization of ACA isoforms and their potential value for crop improvement. We further discuss current challenges in ACA functional characterization, particularly the complexity of Ca2+ signaling networks and the limited understanding of ACA-associated genetic variation. Emerging approaches integrating multi-omics, artificial intelligence, and precision genome editing provide new opportunities for identifying and designing ACA alleles for climate-resilient crop breeding.
Related
- Genome-wide analysis of plasma membrane H+ -ATPases in Populus tomentosa reveals the roles of PtoPHA14D in regulating adventitious root development
- Shaping Slow Manifolds in Equivariant Recurrent Neural Networks
- Host and Environmental Factors Outweigh Pathogen in Shaping Skin Microbiome of a Threatened Andean Amphibian Community
- The role of methylation and structural variants in shaping the recombination landscape of barley
- Role of Extracellular Vesicles in Shaping Immune Responses in the Lymph Node Microenvironment
BibTeX
@article{rui2026plant,
title = {{Plant autoinhibited Ca2+-ATPases: shaping calcium signals for growth, stress adaptation, and crop improvement}},
author = {Mengmeng Rui and Dongdong Xu and Yongsheng Deng and Yizhou Wang and Zongfu Han},
journal = {Frontiers in Plant Science},
year = {2026},
month = nov,
doi = {10.3389/fpls.2026.1984800},
url = {https://www.frontiersin.org/articles/10.3389/fpls.2026.1984800},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Plant autoinhibited Ca2+-ATPases: shaping calcium signals for growth, stress adaptation, and crop improvement
AU - Mengmeng Rui
AU - Dongdong Xu
AU - Yongsheng Deng
AU - Yizhou Wang
AU - Zongfu Han
PY - 2026
DA - 2026/11/06
JO - Frontiers in Plant Science
DO - 10.3389/fpls.2026.1984800
UR - https://www.frontiersin.org/articles/10.3389/fpls.2026.1984800
AB - P-type ATPases are conserved ATP-driven ion transporters that maintain cellular ion homeostasis. Plant P-type IIB Ca2+-ATPases, known as autoinhibited Ca2+-ATPases (ACAs), are key regulators of Ca2+ signaling networks. This review summarizes the structural features, Ca2+/calmodulin-dependent regulation, evolutionary diversification, and biological functions of plant ACAs. By contributing to cytosolic Ca2+ clearance and the restoration of basal Ca2+ levels, ACAs may modulate stimulus-specific Ca2+ dynamics and participate in diverse physiological processes, including plant growth, development, stomatal movement, immunity, and abiotic stress adaptation. Comparative analyses across plant species highlight functional specialization of ACA isoforms and their potential value for crop improvement. We further discuss current challenges in ACA functional characterization, particularly the complexity of Ca2+ signaling networks and the limited understanding of ACA-associated genetic variation. Emerging approaches integrating multi-omics, artificial intelligence, and precision genome editing provide new opportunities for identifying and designing ACA alleles for climate-resilient crop breeding.
SN - 1664-462X
ER -