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Peer-reviewedCC BY 4.0Clinical Case Reports

Medication‐Related Osteonecrosis of the Jaw After Dental Extractions During High‐Dose Denosumab Therapy in a Patient With Paget's Disease: A Case Report

  • Toktam Zamani1
  • Pegah Mosannen Mozaffari2
  • Kazem Anvari3
  • Najmeh Anbiaee4
  • Khashayar Famili5
  • Ali Mirzaei6
  • Fatemeh Fallah Toosi7
  • Abolfazl Shafiee6
7 affiliations
  1. 1Oral & Maxillofacial Diseases Research Center Mashhad University of Medical Sciences Mashhad Iran
  2. 2Oral and Maxillofacial Medicine Scientific Mentor of Shahab Dental Clinic (Oral Medicine and Special Care Dentistry) Mashhad Iran
  3. 3Department of Radiotherapy Oncology and Cancer Research Center Mashhad University of Medical Sciences Mashhad Iran
  4. 4Department of Oral and Maxillofacial Radiology, Oral and Maxillofacial Diseases Research Center Mashhad University of Medical Sciences Mashhad Iran
  5. 5Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Mashhad University of Medical Sciences Mashhad Iran
  6. 6Student Research Committee, Faculty of Dentistry Mashhad University of Medical Sciences Mashhad Iran
  7. 7Faculty of Dentistry Mashhad University of Medical Sciences Mashhad Iran
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Abstract

Patients with Paget's disease who receive high‐dose denosumab may develop medication‐related osteonecrosis of the jaw, particularly after dental extractions. Pre‐treatment dental assessment, careful risk communication, accurate staging, and coordinated conservative and surgical management are essential. Platelet‐rich fibrin may be used only as an adjunct, not as an established standard treatment.

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Cite

BibTeXRIS
BibTeX
@article{zamani2026medicationrelated,
  title = {{Medication‐Related Osteonecrosis of the Jaw After Dental Extractions During High‐Dose Denosumab Therapy in a Patient With Paget's Disease: A Case Report}},
  author = {Toktam Zamani and Pegah Mosannen Mozaffari and Kazem Anvari and Najmeh Anbiaee and Khashayar Famili and Ali Mirzaei and Fatemeh Fallah Toosi and Abolfazl Shafiee},
  journal = {Clinical Case Reports},
  year = {2026},
  month = nov,
  doi = {10.1002/ccr3.73659},
  url = {https://doi.org/10.1002/ccr3.73659},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Medication‐Related Osteonecrosis of the Jaw After Dental Extractions During High‐Dose Denosumab Therapy in a Patient With Paget's Disease: A Case Report
AU  - Toktam Zamani
AU  - Pegah Mosannen Mozaffari
AU  - Kazem Anvari
AU  - Najmeh Anbiaee
AU  - Khashayar Famili
AU  - Ali Mirzaei
AU  - Fatemeh Fallah Toosi
AU  - Abolfazl Shafiee
PY  - 2026
DA  - 2026/11/03
JO  - Clinical Case Reports
DO  - 10.1002/ccr3.73659
UR  - https://doi.org/10.1002/ccr3.73659
AB  - Patients with Paget's disease who receive high‐dose denosumab may develop medication‐related osteonecrosis of the jaw, particularly after dental extractions. Pre‐treatment dental assessment, careful risk communication, accurate staging, and coordinated conservative and surgical management are essential. Platelet‐rich fibrin may be used only as an adjunct, not as an established standard treatment.
SN  - 2050-0904
ER  -