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Peer-reviewedCC BY 4.0Surgery Today

Survival after pulmonary metastasectomy for pancreatobiliary carcinomas: insights from a nationwide multicenter database

  • Taisuke Kaiho1
  • Takahide Toyoda1
  • Hidemi Suzuki1
  • Yoshikane Yamauchi2
  • Noriaki Sakakura3
  • Mingyon Mun4
  • Hiroshi Hashimoto5
  • Takekazu Iwata6
  • Yasushi Shintani7
  • Masayuki Chida8
  • Haruhisa Matsuguma9
  • Keisuke Asakura10
7 more authors
  • Makoto Endo11
  • Tomohiko Iida12
  • Mitsutomo Kohno13
  • Haruhiko Kondo14
  • Norihiko Ikeda15
  • Masaaki Sato16
  • Yukinori Sakao2
16 affiliations
  1. 1Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8670 Japan
  2. 2Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
  3. 3Department of Thoracic Surgery, Aichi Cancer Center, Aichi, Japan
  4. 4Department of Thoracic Surgical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
  5. 5Department of Thoracic Surgery, National Defense Medical College, Saitama, Japan
  6. 6Division of Thoracic Surgery, Chiba Cancer Center, Chiba, Japan
  7. 7Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
  8. 8Department of General Thoracic Surgery, Dokkyo Medical University, Tochigi, Japan
  9. 9Division of Thoracic Surgery, Tochigi Cancer Center, Tochigi, Japan
  10. 10Division of Thoracic Surgery, Department of Surgery, Keio University School of Medicine, Tokyo, Japan
  11. 11Department of Thoracic Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan
  12. 12Department of Thoracic Surgery, Kimitsu Chuo Hospital, Chiba, Japan
  13. 13Department of General Thoracic Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
  14. 14Division of Thoracic and Thyroid Surgery, Kyorin University, Tokyo, Japan
  15. 15Division of Thoracic and Thyroid Surgery, Tokyo Medical University, Tokyo, Japan
  16. 16Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan
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Abstract

Purpose: Pancreatic carcinoma (PC) and biliary tract carcinoma (BTC) may metastasize to the lungs, and surgical resection of these metastases should be considered in selected patients with controlled primary disease. This study evaluated the survival outcomes and prognostic factors in patients who underwent pulmonary metastasectomy for pancreatobiliary carcinoma.

Methods: Seventy-eight patients who underwent lung metastasectomy between 1993 and 2019 were included in the Metastatic Lung Tumor Study Group of the Japan database. The clinicopathological characteristics including overall survival (OS), pulmonary metastasis-free survival (PmFS), and disease-free interval (DFI) from primary surgery to lung metastasectomy were analyzed.

Results: We included 41 men and 37 women with a mean age of 67 years. The primary cancers included 56 PC and 22 BTC cases. Partial resection was performed in 52 patients, segmentectomy in 16, and lobectomy in 10. Five-year OS was 38.3% (43.2% for PC and 28.1% for BTC). Five-year PmFS was 28.3% (28.4% for PC and 27.7% for BTC). The median DFI was 36.0 months (21.0–47.5 months, interquartile range). Larger metastases (> 2 cm) were significantly associated with a poorer survival (hazard ratio, 2.03; 95% confidence interval, 1.06–3.90, p = 0.03).

Conclusion: Lung metastasectomy may be a viable treatment option for select patients with pancreatobiliary carcinoma, particularly those with smaller metastases.

Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00595-026-03389-8.

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Cite

BibTeXRIS
BibTeX
@article{kaiho2026survival,
  title = {{Survival after pulmonary metastasectomy for pancreatobiliary carcinomas: insights from a nationwide multicenter database}},
  author = {Taisuke Kaiho and Takahide Toyoda and Hidemi Suzuki and Yoshikane Yamauchi and Noriaki Sakakura and Mingyon Mun and Hiroshi Hashimoto and Takekazu Iwata and Yasushi Shintani and Masayuki Chida and Haruhisa Matsuguma and Keisuke Asakura and Makoto Endo and Tomohiko Iida and Mitsutomo Kohno and Haruhiko Kondo and Norihiko Ikeda and Masaaki Sato and Yukinori Sakao},
  journal = {Surgery Today},
  year = {2026},
  month = jul,
  doi = {10.1007/s00595-026-03389-8},
  url = {https://doi.org/10.1007/s00595-026-03389-8},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Survival after pulmonary metastasectomy for pancreatobiliary carcinomas: insights from a nationwide multicenter database
AU  - Taisuke Kaiho
AU  - Takahide Toyoda
AU  - Hidemi Suzuki
AU  - Yoshikane Yamauchi
AU  - Noriaki Sakakura
AU  - Mingyon Mun
AU  - Hiroshi Hashimoto
AU  - Takekazu Iwata
AU  - Yasushi Shintani
AU  - Masayuki Chida
AU  - Haruhisa Matsuguma
AU  - Keisuke Asakura
AU  - Makoto Endo
AU  - Tomohiko Iida
AU  - Mitsutomo Kohno
AU  - Haruhiko Kondo
AU  - Norihiko Ikeda
AU  - Masaaki Sato
AU  - Yukinori Sakao
PY  - 2026
DA  - 2026/07/20
JO  - Surgery Today
DO  - 10.1007/s00595-026-03389-8
UR  - https://doi.org/10.1007/s00595-026-03389-8
AB  - Purpose: Pancreatic carcinoma (PC) and biliary tract carcinoma (BTC) may metastasize to the lungs, and surgical resection of these metastases should be considered in selected patients with controlled primary disease. This study evaluated the survival outcomes and prognostic factors in patients who underwent pulmonary metastasectomy for pancreatobiliary carcinoma.  Methods: Seventy-eight patients who underwent lung metastasectomy between 1993 and 2019 were included in the Metastatic Lung Tumor Study Group of the Japan database. The clinicopathological characteristics including overall survival (OS), pulmonary metastasis-free survival (PmFS), and disease-free interval (DFI) from primary surgery to lung metastasectomy were analyzed.  Results: We included 41 men and 37 women with a mean age of 67 years. The primary cancers included 56 PC and 22 BTC cases. Partial resection was performed in 52 patients, segmentectomy in 16, and lobectomy in 10. Five-year OS was 38.3% (43.2% for PC and 28.1% for BTC). Five-year PmFS was 28.3% (28.4% for PC and 27.7% for BTC). The median DFI was 36.0 months (21.0–47.5 months, interquartile range). Larger metastases (> 2 cm) were significantly associated with a poorer survival (hazard ratio, 2.03; 95% confidence interval, 1.06–3.90, p = 0.03).  Conclusion: Lung metastasectomy may be a viable treatment option for select patients with pancreatobiliary carcinoma, particularly those with smaller metastases.  Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00595-026-03389-8.
SN  - 0941-1291
SN  - 1436-2813
ER  -