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Peer-reviewedCC BYSleep science (Sao Paulo, Brazil)

Effect of Long-Term Physical Exercise on Memory, Anxiety-Like Behavior, and Depression in Young and Aged Male Mice Subjected to Sleep Deprivation.

  • Robson Salviano de Matos1,2
  • Paulo Iury Gomes Nunes1,2
  • Bruna Rafaele Diógenes da Silva1,2
  • Daniel Vieira Pinto3
  • Pedro Felipe Carvalhedo de Bruin1,2
  • Reinaldo Barreto Oriá2,4
  • Veralice Meireles Sales de Bruin1,2
4 affiliations
  1. 1Sleep and Biological Rhythms Laboratory, Federal University of Ceara (UFC), Fortaleza, Brazil.
  2. 2Postgraduate Program in Medical Sciences, Federal University of Ceara (UFC), Fortaleza, Brazil.
  3. 3Universidade Nilton Lins, Parque das Laranjeiras, Manaus, Brazil.
  4. 4Laboratory of Wound Healing, Ontogeny, and Tissue Nutrition, Federal University of Ceara (UFC), Fortaleza, Brazil.
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Abstract

This study evaluated whether chronic aerobic exercise could attenuate behavioral impairments associated with sleep deprivation (SD) in young and aged male mice. Young (3 months) and aged (18 months) Swiss mice were assigned to four groups: control, exercise (EXE), sleep deprivation (SD), and exercise followed by SD (EXE + SD). Animals performed treadmill training for 8 weeks and then underwent 72-hour SD. Behavioral tests assessed working memory (Y-maze), depression-like behavior (tail suspension), and anxiety-like behavior (elevated plus maze). The results suggest that age influences the effectiveness of exercise in mitigating sleep deprivation-induced behavioral deficits, opening avenues for future studies on the interaction between physical exercise, sleep, and aging.

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Cite

BibTeXRIS
BibTeX
@article{matos2026effect,
  title = {{Effect of Long-Term Physical Exercise on Memory, Anxiety-Like Behavior, and Depression in Young and Aged Male Mice Subjected to Sleep Deprivation.}},
  author = {Robson Salviano de Matos and Paulo Iury Gomes Nunes and Bruna Rafaele Diógenes da Silva and Daniel Vieira Pinto and Pedro Felipe Carvalhedo de Bruin and Reinaldo Barreto Oriá and Veralice Meireles Sales de Bruin},
  journal = {Sleep science (Sao Paulo, Brazil)},
  year = {2026},
  month = jun,
  doi = {10.1055/s-0046-1829073},
  url = {https://europepmc.org/article/MED/42899062},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Effect of Long-Term Physical Exercise on Memory, Anxiety-Like Behavior, and Depression in Young and Aged Male Mice Subjected to Sleep Deprivation.
AU  - Robson Salviano de Matos
AU  - Paulo Iury Gomes Nunes
AU  - Bruna Rafaele Diógenes da Silva
AU  - Daniel Vieira Pinto
AU  - Pedro Felipe Carvalhedo de Bruin
AU  - Reinaldo Barreto Oriá
AU  - Veralice Meireles Sales de Bruin
PY  - 2026
DA  - 2026/06/01
JO  - Sleep science (Sao Paulo, Brazil)
DO  - 10.1055/s-0046-1829073
UR  - https://europepmc.org/article/MED/42899062
AB  - This study evaluated whether chronic aerobic exercise could attenuate behavioral impairments associated with sleep deprivation (SD) in young and aged male mice. Young (3 months) and aged (18 months) Swiss mice were assigned to four groups: control, exercise (EXE), sleep deprivation (SD), and exercise followed by SD (EXE + SD). Animals performed treadmill training for 8 weeks and then underwent 72-hour SD. Behavioral tests assessed working memory (Y-maze), depression-like behavior (tail suspension), and anxiety-like behavior (elevated plus maze). The results suggest that age influences the effectiveness of exercise in mitigating sleep deprivation-induced behavioral deficits, opening avenues for future studies on the interaction between physical exercise, sleep, and aging.
SN  - 1984-0659
SN  - 1984-0063
ER  -