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Peer-reviewedLicence not statedNature Biotechnology

Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models

  • Akash Gupta1,2
  • R. Das3
  • Kaelan Reed1,2
  • T. Jeon1,2
  • Q. T. C. Nguyen1,2
  • Arnab Rudra1,4,2
  • X. Ge3
  • S. Trongjit1,2
  • Y. S. Vanrobaeys5
  • Róbert Langer1,2
  • Ralph Weissleder3,6,7
  • Christopher Garris8,9
1 more authors
  • Daniel G. Anderson10,11
11 affiliations
  1. 1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
  2. 2Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
  3. 3Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA
  4. 4Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA
  5. 5Bioinformatics & Computing Core Facility of the Swanson Biotechnology Center, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
  6. 6Department of Radiology, Massachusetts General Brigham, Boston, MA, USA
  7. 7Department of Systems Biology, Harvard Medical School, Boston, MA, USA
  8. 8Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA. [email protected]
  9. 9Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. [email protected]
  10. 10David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. [email protected]
  11. 11Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. [email protected]
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Cite

BibTeXRIS
BibTeX
@article{gupta2026immuneremodeling,
  title = {{Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models}},
  author = {Akash Gupta and R. Das and Kaelan Reed and T. Jeon and Q. T. C. Nguyen and Arnab Rudra and X. Ge and S. Trongjit and Y. S. Vanrobaeys and Róbert Langer and Ralph Weissleder and Christopher Garris and Daniel G. Anderson},
  journal = {Nature Biotechnology},
  year = {2026},
  month = may,
  doi = {10.1038/s41587-026-03115-2},
  url = {https://pmc.ncbi.nlm.nih.gov/articles/PMC13242704/},
}
RIS
TY  - JOUR
TI  - Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models
AU  - Akash Gupta
AU  - R. Das
AU  - Kaelan Reed
AU  - T. Jeon
AU  - Q. T. C. Nguyen
AU  - Arnab Rudra
AU  - X. Ge
AU  - S. Trongjit
AU  - Y. S. Vanrobaeys
AU  - Róbert Langer
AU  - Ralph Weissleder
AU  - Christopher Garris
AU  - Daniel G. Anderson
PY  - 2026
DA  - 2026/05/13
JO  - Nature Biotechnology
DO  - 10.1038/s41587-026-03115-2
UR  - https://pmc.ncbi.nlm.nih.gov/articles/PMC13242704/
SN  - 0733-222X
SN  - 1087-0156
SN  - 1546-1696
SN  - 2331-3684
ER  -