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Peer-reviewedCC BY 4.0Journal of Infection

Cardiovascular outcomes and acute human metapneumovirus infection in adults: A systematic literature review

  • Paul Loubet1
  • François Roubille2
  • Odile Launay3
  • Slim Fourati4
  • Fabienne Peretz5
  • Carolina Rojido5
  • Hélène Bricout6
  • Clémence Touron6
  • Oliver Martyn7
7 affiliations
  1. 1VBIC, Univ Montpellier, INSERM, Service des Maladies Infectieuses et Tropicales, CHU Nîmes, Nîmes, France; Correspondence to:Service Maladies infectieuses et tropicales, Centre Hospitalier Universitaire Carémeau, 4 Place du Professeur Robert-Debré, Cedex 9, 30029 Nîmes, France.
  2. 2PhyMedExp, INSERM, CNRS, Cardiology Department, INI-CRT, Université de Montpellier, Montpellier 34295, France
  3. 3AP-HP, Hôpital Cochin, CIC Cochin Pasteur, Paris, France; Inserm, CIC 1417, Paris, France; Université Paris Cité, Hôpital Cochin, CIC Cochin Pasteur, Paris, France
  4. 4Department of Virology, Hôpitaux Universitaires Henri Mondor, Assistance Publique - Hôpitaux de Paris, Institut Mondor, INSERM U955, Team ''Viruses, Hepatology, Cancer'', Université Paris-Est-Créteil (UPEC), Créteil, France
  5. 5Abelia Science, Auxerre, France
  6. 6Sanofi Vaccines, Lyon, France
  7. 7Sanofi Vaccines, Copenhagen, Denmark
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Abstract

Objectives: Acute respiratory viral infections, including influenza, RSV, and SARS-CoV-2, are well-recognized as being associated with cardiovascular events (CVEs). In contrast, the cardiovascular impact of human metapneumovirus (HMPV) remains poorly characterized. We aimed to describe the prevalence of pre-existing cardiovascular diseases (CVDs) and the incidence of acute CVEs in adults with laboratory-confirmed HMPV infection. Methods: PRISMA-guided systematic literature review of MEDLINE, Embase, and Google Scholar (Jan.–2000/Sept.–2025). Observational studies and clinical trials reporting pre-existing CVDs and/or CVEs in adults (≥18 years) were included. Results: Eighteen studies met the inclusion criteria, of which nine underwent critical appraisal. Most involved hospitalized older adults. Pre-existing CVD was reported in 10%–80% of HMPV-infected patients, with chronic heart failure and coronary artery disease being the most common conditions. Acute CVEs, particularly heart failure exacerbations, occurred in 5%–25% of hospitalized patients. Underlying CVD was consistently linked to increased severity of HMPV illness, including higher rates of ICU admission and mortality. Conclusions: Acute HMPV infection frequently occurs in adults with pre-existing CVD and may be associated with CVEs in older hospitalized populations. However, evidence remains limited and largely observational. These findings highlight the need to increase awareness of the potential CV complications associated with HMPV infection. Trial registration: PROSPERO [CRD420251164583]

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Cite

BibTeXRIS
BibTeX
@article{loubet2026cardiovascular,
  title = {{Cardiovascular outcomes and acute human metapneumovirus infection in adults: A systematic literature review}},
  author = {Paul Loubet and François Roubille and Odile Launay and Slim Fourati and Fabienne Peretz and Carolina Rojido and Hélène Bricout and Clémence Touron and Oliver Martyn},
  journal = {Journal of Infection},
  year = {2026},
  month = oct,
  doi = {10.1016/j.jinf.2026.106843},
  url = {https://doi.org/10.1016/j.jinf.2026.106843},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Cardiovascular outcomes and acute human metapneumovirus infection in adults: A systematic literature review
AU  - Paul Loubet
AU  - François Roubille
AU  - Odile Launay
AU  - Slim Fourati
AU  - Fabienne Peretz
AU  - Carolina Rojido
AU  - Hélène Bricout
AU  - Clémence Touron
AU  - Oliver Martyn
PY  - 2026
DA  - 2026/10/23
JO  - Journal of Infection
DO  - 10.1016/j.jinf.2026.106843
UR  - https://doi.org/10.1016/j.jinf.2026.106843
AB  - Objectives: Acute respiratory viral infections, including influenza, RSV, and SARS-CoV-2, are well-recognized as being associated with cardiovascular events (CVEs). In contrast, the cardiovascular impact of human metapneumovirus (HMPV) remains poorly characterized. We aimed to describe the prevalence of pre-existing cardiovascular diseases (CVDs) and the incidence of acute CVEs in adults with laboratory-confirmed HMPV infection. Methods: PRISMA-guided systematic literature review of MEDLINE, Embase, and Google Scholar (Jan.–2000/Sept.–2025). Observational studies and clinical trials reporting pre-existing CVDs and/or CVEs in adults (≥18 years) were included. Results: Eighteen studies met the inclusion criteria, of which nine underwent critical appraisal. Most involved hospitalized older adults. Pre-existing CVD was reported in 10%–80% of HMPV-infected patients, with chronic heart failure and coronary artery disease being the most common conditions. Acute CVEs, particularly heart failure exacerbations, occurred in 5%–25% of hospitalized patients. Underlying CVD was consistently linked to increased severity of HMPV illness, including higher rates of ICU admission and mortality. Conclusions: Acute HMPV infection frequently occurs in adults with pre-existing CVD and may be associated with CVEs in older hospitalized populations. However, evidence remains limited and largely observational. These findings highlight the need to increase awareness of the potential CV complications associated with HMPV infection. Trial registration: PROSPERO [CRD420251164583]
SN  - 1532-2742
SN  - 0163-4453
ER  -