Tunable Poly(acrylamide- co -HEMA) Hydrogel Intraocular Lenses for Canine Ophthalmic Applications
- 1Chulalongkorn University , , ,
- 2University of Waterloo , , , ,
Abstract
A soft hydrogel intraocular lens (IOL) based on poly(acrylamide-co-2-hydroxyethyl methacrylate) (poly(AAm-co-HEMA)) was developed as a tunable material platform for canine ophthalmic applications, addressing the limited exploration of hydrogel-based IOL materials in veterinary use. By systematically varying the AAm:HEMA composition, the hydration, surface, mechanical, optical, and cytocompatibility properties were evaluated to identify a formulation with a favorable overall balance of material characteristics. The selected hydrogel formulation, consisting of 18% (w/v) total monomer content with an AAm:HEMA ratio of 90:10, exhibited high visible-light transmittance (99.31 ± 0.05%), favorable wettability (16.69 ± 1.03°), a swelling ratio of 31.71 ± 2.06%, an elastic modulus of 45.96 ± 10.55 kPa, and high cytocompatibility (97.23 ± 8.40% cell viability). Functional imaging using a USAF 1951 resolution target further showed spatial resolution and image contrast comparable to a commercial IOL under the tested conditions. At the investigated lens geometry, the selected 90:10 formulation exhibited an optical power of 29.16 ± 0.54 D. Preliminary injector-assisted delivery also demonstrated folding and recovery of the overall IOL configuration without visible structural damage. Although the measured optical power was below the typical 35–40 D range for canine IOLs, adjustment of optic curvature and thickness provides a route toward the required optical power, while accounting for hydration-dependent dimensional and optical changes. Overall, the developed composition–geometry platform enables material properties and lens geometry to be considered as complementary design parameters, providing a foundation for further canine-specific geometric, biological, ex vivo, and in vivo evaluation.
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BibTeX
@article{chiradejnant2026tunable,
title = {{Tunable Poly(acrylamide- co -HEMA) Hydrogel Intraocular Lenses for Canine Ophthalmic Applications}},
author = {Anya Chiradejnant and Suwat Romphosri and Theerapat Chanamuangkon and Titima Lertsrisatit and Orapun Jaturakan and Nalinee Tuntivanich and Sushanta K. Mitra and Charusluk Viphavakit},
journal = {ACS Omega},
year = {2026},
month = oct,
doi = {10.1021/acsomega.6c07873},
url = {https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c07873/5458102/Tunable-Poly-acrylamide-co-HEMA-Hydrogel},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Tunable Poly(acrylamide- co -HEMA) Hydrogel Intraocular Lenses for Canine Ophthalmic Applications
AU - Anya Chiradejnant
AU - Suwat Romphosri
AU - Theerapat Chanamuangkon
AU - Titima Lertsrisatit
AU - Orapun Jaturakan
AU - Nalinee Tuntivanich
AU - Sushanta K. Mitra
AU - Charusluk Viphavakit
PY - 2026
DA - 2026/10/26
JO - ACS Omega
DO - 10.1021/acsomega.6c07873
UR - https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c07873/5458102/Tunable-Poly-acrylamide-co-HEMA-Hydrogel
AB - A soft hydrogel intraocular lens (IOL) based on poly(acrylamide-co-2-hydroxyethyl methacrylate) (poly(AAm-co-HEMA)) was developed as a tunable material platform for canine ophthalmic applications, addressing the limited exploration of hydrogel-based IOL materials in veterinary use. By systematically varying the AAm:HEMA composition, the hydration, surface, mechanical, optical, and cytocompatibility properties were evaluated to identify a formulation with a favorable overall balance of material characteristics. The selected hydrogel formulation, consisting of 18% (w/v) total monomer content with an AAm:HEMA ratio of 90:10, exhibited high visible-light transmittance (99.31 ± 0.05%), favorable wettability (16.69 ± 1.03°), a swelling ratio of 31.71 ± 2.06%, an elastic modulus of 45.96 ± 10.55 kPa, and high cytocompatibility (97.23 ± 8.40% cell viability). Functional imaging using a USAF 1951 resolution target further showed spatial resolution and image contrast comparable to a commercial IOL under the tested conditions. At the investigated lens geometry, the selected 90:10 formulation exhibited an optical power of 29.16 ± 0.54 D. Preliminary injector-assisted delivery also demonstrated folding and recovery of the overall IOL configuration without visible structural damage. Although the measured optical power was below the typical 35–40 D range for canine IOLs, adjustment of optic curvature and thickness provides a route toward the required optical power, while accounting for hydration-dependent dimensional and optical changes. Overall, the developed composition–geometry platform enables material properties and lens geometry to be considered as complementary design parameters, providing a foundation for further canine-specific geometric, biological, ex vivo, and in vivo evaluation.
SN - 2470-1343
ER -