Endoscopic therapy for gastrointestinal bleeding in Klippel–Trénaunay syndrome: a case report and literature review
- 1Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , ,
Abstract
Background
Klippel-Trénaunay syndrome (KTS) is a rare congenital vascular anomaly characterized by capillary malformation, underlying low-flow venous/lymphatic malformations, and bone- and/or soft-tissue limb hypertrophy of the affected extremity. At present, there is no consensus on the optimal management of KTS, particularly in the context of gastrointestinal bleeding.Case presentation
We describe a case of gastrointestinal bleeding in a patient with KTS who presented with colorectal venous malformations with phleboliths, multiple splenic vascular malformations, penile varicosities, and hypertrophy of the right lower extremity and the right buttock. A colonoscopy revealed a circumferential mucosal elevation with bluish discoloration extending from 15 cm above the anal verge in the colorectum, and active bleeding was observed at 12 cm from the anal verge. Endoscopic submucosal sclerotherapy with 1-1.5 mL of lauromacrogol (1%) per site and a total volume of 30 mL, combined with band ligation using six bands, was performed. This approach has rarely been reported and resulted in significant relief from bleeding. At the 6-month follow-up, the patient's symptoms and hemoglobin levels remained stable, with no other complications.Conclusion
Although KTS remains incurable, early endoscopic recognition facilitates diagnosis, and endoscopic therapy may serve as an important treatment modality for gastrointestinal involvement.
Related
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BibTeX
@article{zhang2026endoscopic,
title = {{Endoscopic therapy for gastrointestinal bleeding in Klippel–Trénaunay syndrome: a case report and literature review}},
author = {Ruoxi Zhang and Wen Shi and Xi Wu and Aiming Yang and Yang Chen},
journal = {Frontiers in medicine},
year = {2026},
month = oct,
doi = {10.3389/fmed.2026.1960274},
url = {https://europepmc.org/article/PMC/PMC13716628},
note = {CC BY},
}
RIS
TY - JOUR
TI - Endoscopic therapy for gastrointestinal bleeding in Klippel–Trénaunay syndrome: a case report and literature review
AU - Ruoxi Zhang
AU - Wen Shi
AU - Xi Wu
AU - Aiming Yang
AU - Yang Chen
PY - 2026
DA - 2026/10/15
JO - Frontiers in medicine
DO - 10.3389/fmed.2026.1960274
UR - https://europepmc.org/article/PMC/PMC13716628
AB - Background Klippel-Trénaunay syndrome (KTS) is a rare congenital vascular anomaly characterized by capillary malformation, underlying low-flow venous/lymphatic malformations, and bone- and/or soft-tissue limb hypertrophy of the affected extremity. At present, there is no consensus on the optimal management of KTS, particularly in the context of gastrointestinal bleeding.Case presentation We describe a case of gastrointestinal bleeding in a patient with KTS who presented with colorectal venous malformations with phleboliths, multiple splenic vascular malformations, penile varicosities, and hypertrophy of the right lower extremity and the right buttock. A colonoscopy revealed a circumferential mucosal elevation with bluish discoloration extending from 15 cm above the anal verge in the colorectum, and active bleeding was observed at 12 cm from the anal verge. Endoscopic submucosal sclerotherapy with 1-1.5 mL of lauromacrogol (1%) per site and a total volume of 30 mL, combined with band ligation using six bands, was performed. This approach has rarely been reported and resulted in significant relief from bleeding. At the 6-month follow-up, the patient's symptoms and hemoglobin levels remained stable, with no other complications.Conclusion Although KTS remains incurable, early endoscopic recognition facilitates diagnosis, and endoscopic therapy may serve as an important treatment modality for gastrointestinal involvement.
SN - 2296-858X
ER -