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Peer-reviewedCC BYBMC musculoskeletal disorders

Ultrasonographic evaluation of fibrous structure and mechanical characteristics of the infrapatellar fat pad in female patients with knee osteoarthritis: a cross-sectional study.

  • Syoya Nakanishi1,2
  • Masahiro Tsutsumi1,3
  • Takashi Kitagawa1,4
  • Toshinori Miyashita3,5
  • Kei Narui2
  • Makoto Wada2
  • Shintarou Kudo6,7,8
8 affiliations
  1. 1Graduate School of Health Sciences, Morinomiya University of Medical Sciences, 1-26-16 Nankoukita, Suminoe-ward, Osaka, 559-8611, Japan.
  2. 2Wada Orthopedic Clinic, Osaka, Japan.
  3. 3Inclusive Medical Sciences Research Institute, Morinomiya University of Medical Sciences, Osaka, Japan.
  4. 4Department of Rehabilitation, Higashiosaka Hospital, Osaka, Japan.
  5. 5Osaka Bay Clinic, Morinomiya University of Medical Sciences, Osaka, Japan.
  6. 6Graduate School of Health Sciences, Morinomiya University of Medical Sciences, 1-26-16 Nankoukita, Suminoe-ward, Osaka, 559-8611, Japan. [email protected].
  7. 7Inclusive Medical Sciences Research Institute, Morinomiya University of Medical Sciences, Osaka, Japan. [email protected].
  8. 8AR-Ex Medical Research Center, Tokyo, Japan. [email protected].
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Abstract

Background

Fibrosis of the infrapatellar fat pad (IFP) is common in knee osteoarthritis (KOA); however, a comprehensive evaluation is lacking. This study aimed to use ultrasonography to investigate the fibrous structure and mechanical characteristics of the IFP in patients with KOA.Methods

This cross-sectional study included patients with KOA, age-matched controls, and healthy young adults. Fifty knees with KOA were analyzed for Kellgren-Lawrence grade differences, whereas 50 knees with KOA, 14 age-matched controls, and 15 knees from healthy young adults were analyzed for between-group comparisons. The primary outcomes were IFP shear wave stiffness, fiber orientation intensity, proportion of high-intensity area, and movement, assessed using shear wave elastography, ImageJ analysis, binarized US analysis, and particle image velocimetry, respectively. The association between magnetic resonance imaging (MRI) signal intensity and outcomes was evaluated in the KOA group.Results

Compared with the controls, the KOA group demonstrated greater IFP stiffness (95% confidence interval [CI] [0.152, 0.469]) and proportion of high-intensity area (95% CI [2.737, 11.263]) with reduced movement of the superficial part (95% CI [-0.240, -0.104]) and the deep part (95% CI [-0.290, -0.131]). MRI signal intensity of the IFP was positively correlated with the proportion of high-intensity area among the 14 KOA knees with MRI data (r = 0.720, p = 0.004). The proportion of high-intensity area in grade IV was significantly higher than that in grades I and II.Conclusion

IFP in KOA exhibits distinct ultrasonographic characteristics, including increased stiffness and proportion of high-intensity area, along with restricted movement. Notably, the proportion of high-intensity area was significantly higher in KL grade IV than grades I and II, and correlated with MRI signal intensity, suggesting its potential utility as a quantitative ultrasound-derived imaging parameter for assessing IFP tissue alteration in KOA.

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Cite

BibTeXRIS
BibTeX
@article{nakanishi2026ultrasonographic,
  title = {{Ultrasonographic evaluation of fibrous structure and mechanical characteristics of the infrapatellar fat pad in female patients with knee osteoarthritis: a cross-sectional study.}},
  author = {Syoya Nakanishi and Masahiro Tsutsumi and Takashi Kitagawa and Toshinori Miyashita and Kei Narui and Makoto Wada and Shintarou Kudo},
  journal = {BMC musculoskeletal disorders},
  year = {2026},
  month = jul,
  doi = {10.1186/s12891-026-10250-z},
  url = {https://europepmc.org/article/MED/42897532},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Ultrasonographic evaluation of fibrous structure and mechanical characteristics of the infrapatellar fat pad in female patients with knee osteoarthritis: a cross-sectional study.
AU  - Syoya Nakanishi
AU  - Masahiro Tsutsumi
AU  - Takashi Kitagawa
AU  - Toshinori Miyashita
AU  - Kei Narui
AU  - Makoto Wada
AU  - Shintarou Kudo
PY  - 2026
DA  - 2026/07/01
JO  - BMC musculoskeletal disorders
DO  - 10.1186/s12891-026-10250-z
UR  - https://europepmc.org/article/MED/42897532
AB  - Background  Fibrosis of the infrapatellar fat pad (IFP) is common in knee osteoarthritis (KOA); however, a comprehensive evaluation is lacking. This study aimed to use ultrasonography to investigate the fibrous structure and mechanical characteristics of the IFP in patients with KOA.Methods  This cross-sectional study included patients with KOA, age-matched controls, and healthy young adults. Fifty knees with KOA were analyzed for Kellgren-Lawrence grade differences, whereas 50 knees with KOA, 14 age-matched controls, and 15 knees from healthy young adults were analyzed for between-group comparisons. The primary outcomes were IFP shear wave stiffness, fiber orientation intensity, proportion of high-intensity area, and movement, assessed using shear wave elastography, ImageJ analysis, binarized US analysis, and particle image velocimetry, respectively. The association between magnetic resonance imaging (MRI) signal intensity and outcomes was evaluated in the KOA group.Results  Compared with the controls, the KOA group demonstrated greater IFP stiffness (95% confidence interval [CI] [0.152, 0.469]) and proportion of high-intensity area (95% CI [2.737, 11.263]) with reduced movement of the superficial part (95% CI [-0.240, -0.104]) and the deep part (95% CI [-0.290, -0.131]). MRI signal intensity of the IFP was positively correlated with the proportion of high-intensity area among the 14 KOA knees with MRI data (r = 0.720, p = 0.004). The proportion of high-intensity area in grade IV was significantly higher than that in grades I and II.Conclusion  IFP in KOA exhibits distinct ultrasonographic characteristics, including increased stiffness and proportion of high-intensity area, along with restricted movement. Notably, the proportion of high-intensity area was significantly higher in KL grade IV than grades I and II, and correlated with MRI signal intensity, suggesting its potential utility as a quantitative ultrasound-derived imaging parameter for assessing IFP tissue alteration in KOA.
SN  - 1471-2474
ER  -