Necrotizing Fasciitis Caused by Serotype 7C Streptococcus pneumoniae in Overwhelming Post-splenectomy…

Abstract

Overwhelming post-splenectomy infection is a life-threatening condition typically caused by Streptococcus pneumoniae. Necrotizing fasciitis is a rare manifestation of invasive pneumococcal disease. A 73-year-old woman with a history of living-donor liver transplantation and splenectomy for primary biliary cholangitis presented with bilateral leg swelling, pain and altered consciousness. S. pneumoniae serotype 7C, sequence type 2758, was isolated from the blood and wound cultures. Despite intensive care and surgery, the patient developed liver graft failure and died on day 42. The emergence of non-vaccine serotypes highlights the urgent need for next-generation vaccines that target emerging strains.

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BibTeX RIS

BibTeX

@article{akazawa2026necrotizing,
  title = {{Necrotizing Fasciitis Caused by Serotype 7C Streptococcus pneumoniae in Overwhelming Post-splenectomy Infection}},
  author = {Hidemasa Akazawa and Shinnosuke Fukushima and Kenta Nakamoto and Kohei Oguni and Bin Chang and Yukihiro Akeda and Satoru Sugihara and Miyu Takenaka and Shin Morizane and Hideharu Hagiya},
  journal = {Internal Medicine},
  year = {2026},
  month = aug,
  doi = {10.2169/internalmedicine.6637-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_6637-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Necrotizing Fasciitis Caused by Serotype 7C Streptococcus pneumoniae in Overwhelming Post-splenectomy Infection
AU  - Hidemasa Akazawa
AU  - Shinnosuke Fukushima
AU  - Kenta Nakamoto
AU  - Kohei Oguni
AU  - Bin Chang
AU  - Yukihiro Akeda
AU  - Satoru Sugihara
AU  - Miyu Takenaka
AU  - Shin Morizane
AU  - Hideharu Hagiya
PY  - 2026
DA  - 2026/08/01
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6637-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_6637-25/_article
AB  - Overwhelming post-splenectomy infection is a life-threatening condition typically caused by Streptococcus pneumoniae. Necrotizing fasciitis is a rare manifestation of invasive pneumococcal disease. A 73-year-old woman with a history of living-donor liver transplantation and splenectomy for primary biliary cholangitis presented with bilateral leg swelling, pain and altered consciousness. S. pneumoniae serotype 7C, sequence type 2758, was isolated from the blood and wound cultures. Despite intensive care and surgery, the patient developed liver graft failure and died on day 42. The emergence of non-vaccine serotypes highlights the urgent need for next-generation vaccines that target emerging strains.
SN  - 1349-7235
SN  - 0918-2918
ER  -

Abstract

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