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PreprintCC BY-SA 4.0arXiv

Phase separating microdomains in highly coarse-grained lipids

  • S. Siva Nasarayya Chari
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Abstract

A highly coarse-grained model for the lipid monolayer is formulated by considering a two-dimensional system of spherical particles with distinct types of S, U, and C, corresponding to the saturated, unsaturated, and cholesterol molecules. Their interactions are defined as modified Lennard-Jones type with distinct interaction strengths. The phase behavior of the system is studied for various cholesterol compositions, x ranging from 0.1 to 0.6. From the simulation results, we observe that the S- and C-type particles segregate together to form ordered microdomains, with U-type particles at their outer leaflet; consistent with observations in literature. An order parameter Φ is defined to quantify the extent of phase separation among the constituents. The time averaged value of Φ is found increasing with the x value. Radial distribution function calculations indicate the structural ordering within the phase separated domains.

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Cite

BibTeXRIS
BibTeX
@misc{chari2026phase,
  title = {{Phase separating microdomains in highly coarse-grained lipids}},
  author = {S. Siva Nasarayya Chari},
  howpublished = {arXiv},
  year = {2026},
  month = oct,
  doi = {10.48550/arxiv.2610.18882},
  eprint = {2610.18882},
  archivePrefix = {arXiv},
  url = {https://arxiv.org/abs/2610.18882},
  note = {CC BY-SA 4.0},
}
RIS
TY  - UNPB
TI  - Phase separating microdomains in highly coarse-grained lipids
AU  - S. Siva Nasarayya Chari
PY  - 2026
DA  - 2026/10/01
PB  - arXiv
DO  - 10.48550/arxiv.2610.18882
UR  - https://arxiv.org/abs/2610.18882
AB  - A highly coarse-grained model for the lipid monolayer is formulated by considering a two-dimensional system of spherical particles with distinct types of S, U, and C, corresponding to the saturated, unsaturated, and cholesterol molecules. Their interactions are defined as modified Lennard-Jones type with distinct interaction strengths. The phase behavior of the system is studied for various cholesterol compositions, x ranging from 0.1 to 0.6. From the simulation results, we observe that the S- and C-type particles segregate together to form ordered microdomains, with U-type particles at their outer leaflet; consistent with observations in literature. An order parameter Φ is defined to quantify the extent of phase separation among the constituents. The time averaged value of Φ is found increasing with the x value. Radial distribution function calculations indicate the structural ordering within the phase separated domains.
ER  -