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Peer-reviewedCC BYTrends open

Harnessing gastrointestinal motility for advancing diagnostics and therapeutics.

  • Shonit N Sharma1,2,3
  • Akash A Pai2,3
  • Noah J Selda2,3
  • Xiangang Huang3,4
  • Nimrat Kaur2,3
  • Wei Tao3,4
  • Jeffrey M Karp2,3,4,5,6,7
  • Yuhan Lee2,3,4
7 affiliations
  1. 1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  2. 2Center for Accelerated Medical Innovation, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  3. 3Center for Nanomedicine, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  4. 4Harvard Medical School, Boston, MA, USA.
  5. 5Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.
  6. 6Harvard Stem Cell Institute, Cambridge, MA, USA.
  7. 7Broad Institute of MIT and Harvard, Cambridge, MA, USA.
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Abstract

Gastrointestinal (GI) motility plays a fundamental role in digestion, metabolism, immunity, and drug absorption. Yet, many current diagnostic and therapeutic devices designed for the GI tract overlook its dynamic mechanics, compromising their effectiveness and reliability. In this review, we provide a comprehensive overview of GI motility metrics, current devices and their limitations, and how a deeper understanding of motility can improve device design. We also highlight sex-specific differences in GI motility and their implications for clinical translation. We offer a perspective for a new approach that embeds standardized motility metrics into device development, thus improving diagnostic accuracy and personalizing therapies. By emphasizing physiology-guided design principles, future ingestible devices could adapt in real time to individual motility patterns, thereby transforming patient care.

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Cite

BibTeXRIS
BibTeX
@article{sharma2026harnessing,
  title = {{Harnessing gastrointestinal motility for advancing diagnostics and therapeutics.}},
  author = {Shonit N Sharma and Akash A Pai and Noah J Selda and Xiangang Huang and Nimrat Kaur and Wei Tao and Jeffrey M Karp and Yuhan Lee},
  journal = {Trends open},
  year = {2026},
  month = oct,
  doi = {10.1016/j.treopn.2026.09.002},
  url = {https://europepmc.org/article/MED/42948418},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Harnessing gastrointestinal motility for advancing diagnostics and therapeutics.
AU  - Shonit N Sharma
AU  - Akash A Pai
AU  - Noah J Selda
AU  - Xiangang Huang
AU  - Nimrat Kaur
AU  - Wei Tao
AU  - Jeffrey M Karp
AU  - Yuhan Lee
PY  - 2026
DA  - 2026/10/06
JO  - Trends open
DO  - 10.1016/j.treopn.2026.09.002
UR  - https://europepmc.org/article/MED/42948418
AB  - Gastrointestinal (GI) motility plays a fundamental role in digestion, metabolism, immunity, and drug absorption. Yet, many current diagnostic and therapeutic devices designed for the GI tract overlook its dynamic mechanics, compromising their effectiveness and reliability. In this review, we provide a comprehensive overview of GI motility metrics, current devices and their limitations, and how a deeper understanding of motility can improve device design. We also highlight sex-specific differences in GI motility and their implications for clinical translation. We offer a perspective for a new approach that embeds standardized motility metrics into device development, thus improving diagnostic accuracy and personalizing therapies. By emphasizing physiology-guided design principles, future ingestible devices could adapt in real time to individual motility patterns, thereby transforming patient care.
SN  - 3117-3470
ER  -