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A phenotype-structured Cahn-Hilliard model

  • Benoît Perthame
  • Alexandre Poulain
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Abstract

We propose a phenotype-structure form of the Cahn-Hilliard equation with degenerate mobility and analyze the existence of weak solutions for this new variant. This model is motivated by tumor modeling as multiple phenotypes co-exist within the same tumor and are believed to constitute a continuum of phenotypes. The originality of the model lies in its ability to consider an infinite number of phases and it allows for spatial interactions between phenotypes as well as transport in the phenotypic space, i.e., mutations.

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Cite

BibTeXRIS
BibTeX
@misc{perthame2026phenotypestructured,
  title = {{A phenotype-structured Cahn-Hilliard model}},
  author = {Benoît Perthame and Alexandre Poulain},
  howpublished = {HAL},
  year = {2026},
  month = oct,
  doi = {10.48550/arxiv.2610.40869},
  eprint = {2610.40869},
  archivePrefix = {arXiv},
  url = {https://hal.science/hal-05841274v1},
}
RIS
TY  - UNPB
TI  - A phenotype-structured Cahn-Hilliard model
AU  - Benoît Perthame
AU  - Alexandre Poulain
PY  - 2026
DA  - 2026/10/27
PB  - HAL
DO  - 10.48550/arxiv.2610.40869
UR  - https://hal.science/hal-05841274v1
AB  - We propose a phenotype-structure form of the Cahn-Hilliard equation with degenerate mobility and analyze the existence of weak solutions for this new variant. This model is motivated by tumor modeling as multiple phenotypes co-exist within the same tumor and are believed to constitute a continuum of phenotypes. The originality of the model lies in its ability to consider an infinite number of phases and it allows for spatial interactions between phenotypes as well as transport in the phenotypic space, i.e., mutations.
ER  -