Initial psychometric evaluation of the Lipedema Quality of Life questionnaire in females with lipedema in Norway.
6 affiliations
- 1Nord-Trøndelag Hospital Trust, Clinic of Surgery, Namsos Hospital, Namsos, Norway.
- 2Department of Health and Caring Sciences, Western Norway University of Applied Sciences, Førde, Norway.
- 3Department of Research and Innovation, Førde Hospital Trust, Førde, Norway.
- 4Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
- 5Medical Practice for Vascular Diseases, Hof, Germany.
- 6Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Abstract
Background
There are no validated Norwegian disease-specific patient-reported outcome measures (PROMs) assessing quality of life (QoL) in females with lipedema, limiting evaluation of treatment effect in clinical practice and research.Objective
To translate and validate a Norwegian translation of the LIPQOL questionnaire.Methods
A cross-sectional validation study was performed in 432 females with lipedema in Norway. Descriptive statistics and floor and ceiling effects were assessed. The psychometric properties of the questionnaire were assessed using confirmatory factor analysis (CFA). The overall goodness of fit was evaluated using the root mean square error of approximation (RMSEA), the comparative fit index (CFI) and the Tucker-Lewis index (TLI). Internal consistency was assessed using composite reliability from the CFA. Associations between LIPQOL subscales and RAND-12 physical component score (PCS) and mental component score (MCS) were examined using Spearman correlations.Results
The LIPQOL questionnaire comprises four subscales, Function, Body image, Symptoms, and Feelings. No subscales was affected by floor or ceiling effects. The unmodified CFA shows CFI = 0.929, TLI = 0.922, standardized root mean square residual (SRMR) = 0.073, and RMSEA = 0.079 (90% CI: 0.073 to 0.084). All composite reliability were considered reasonable (ranged from 0.890 to 0.916). Modification indices were evaluated, and two modifications were performed between items 5 and 8, and between items 17 and 18. With modification indices, the overall structure validity showed reasonable, but not unequivocally support for the four factor structure with CFI = 0.944, and TLI = 0.938, SRMR = 0.068, and RMSEA = 0.070 (90% CI: 0.064 to 0.075). Correlation between RAND-12 and LIPQOL subscales were large. Function, Symptoms, and overall quality of life show large correlation with PCS (Spearman's rho = -0.682, Spearman's rho = -0.550, and Spearman's rho = 0.554, respectively) and the subscales feelings and overall quality of life shows large correlation with MCS from RAND-12 (Spearman's rho = -0.685 and 0.608, respectively).Conclusion
Initial findings suggest that the Norwegian version of the LIPQOL is a reasonably valid instrument for assessing quality of life in females with lipedema, although the findings do not provide unequivocal support for all aspects of its measurement properties.
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BibTeX
@article{lundanes2026initial,
title = {{Initial psychometric evaluation of the Lipedema Quality of Life questionnaire in females with lipedema in Norway.}},
author = {Julianne Lundanes and John Roger Andersen and Jutta Dierkes and Klaus Schrader and Siren Nymo},
journal = {Frontiers in global women's health},
year = {2026},
month = oct,
doi = {10.3389/fgwh.2026.1917274},
url = {https://europepmc.org/article/MED/42921064},
note = {CC BY},
}
RIS
TY - JOUR
TI - Initial psychometric evaluation of the Lipedema Quality of Life questionnaire in females with lipedema in Norway.
AU - Julianne Lundanes
AU - John Roger Andersen
AU - Jutta Dierkes
AU - Klaus Schrader
AU - Siren Nymo
PY - 2026
DA - 2026/10/09
JO - Frontiers in global women's health
DO - 10.3389/fgwh.2026.1917274
UR - https://europepmc.org/article/MED/42921064
AB - Background There are no validated Norwegian disease-specific patient-reported outcome measures (PROMs) assessing quality of life (QoL) in females with lipedema, limiting evaluation of treatment effect in clinical practice and research.Objective To translate and validate a Norwegian translation of the LIPQOL questionnaire.Methods A cross-sectional validation study was performed in 432 females with lipedema in Norway. Descriptive statistics and floor and ceiling effects were assessed. The psychometric properties of the questionnaire were assessed using confirmatory factor analysis (CFA). The overall goodness of fit was evaluated using the root mean square error of approximation (RMSEA), the comparative fit index (CFI) and the Tucker-Lewis index (TLI). Internal consistency was assessed using composite reliability from the CFA. Associations between LIPQOL subscales and RAND-12 physical component score (PCS) and mental component score (MCS) were examined using Spearman correlations.Results The LIPQOL questionnaire comprises four subscales, Function, Body image, Symptoms, and Feelings. No subscales was affected by floor or ceiling effects. The unmodified CFA shows CFI = 0.929, TLI = 0.922, standardized root mean square residual (SRMR) = 0.073, and RMSEA = 0.079 (90% CI: 0.073 to 0.084). All composite reliability were considered reasonable (ranged from 0.890 to 0.916). Modification indices were evaluated, and two modifications were performed between items 5 and 8, and between items 17 and 18. With modification indices, the overall structure validity showed reasonable, but not unequivocally support for the four factor structure with CFI = 0.944, and TLI = 0.938, SRMR = 0.068, and RMSEA = 0.070 (90% CI: 0.064 to 0.075). Correlation between RAND-12 and LIPQOL subscales were large. Function, Symptoms, and overall quality of life show large correlation with PCS (Spearman's rho = -0.682, Spearman's rho = -0.550, and Spearman's rho = 0.554, respectively) and the subscales feelings and overall quality of life shows large correlation with MCS from RAND-12 (Spearman's rho = -0.685 and 0.608, respectively).Conclusion Initial findings suggest that the Norwegian version of the LIPQOL is a reasonably valid instrument for assessing quality of life in females with lipedema, although the findings do not provide unequivocal support for all aspects of its measurement properties.
SN - 2673-5059
ER -