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Peer-reviewedCC BYFrontiers in endocrinology

Coupling characteristics of endocrine regulation and system function under massage interventions.

4 affiliations
  1. 1The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
  2. 2Guangxi University of Chinese Medicine Graduate School, Nanning, Guangxi, China.
  3. 3First Affiliated Hospital of the Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
  4. 4Faculty of Chinese Medicine Science Guangxi University of Chinese Medicine, Nanning, Guangxi, China.

Abstract

Introduction

Massage may influence stress related endocrine activity and systemic physiological function, but its dynamic regulatory effects remain difficult to quantify.Methods

This study develops a VariationalMotionBayesian framework to model endocrine related physiological responses under massage intervention. The framework combines mathematical formulation of coupled endocrine and systemic variables, variational latent representation learning, motion field estimation, Bayesian evidence aggregation, and physiological constraint regularization. Multimodal wearable physiological time series are used to infer latent regulatory states and predict individual stress status.Results and discussion

Experiments on WESAD and SWELL-KW show that the proposed model outperforms conventional machine learning, deep learning, and time series classification baselines in Accuracy, Macro F1, Balanced Accuracy, and AUROC. A controlled human massage intervention pilot study further shows coordinated changes in salivary cortisol, salivary alpha amylase, heart rate, RMSSD, electrodermal activity, respiration rate, and skin temperature after massage, and these measured responses are correlated with model derived latent dynamics. These results indicate that the proposed framework can capture physiologically meaningful temporal responses and provide a computational tool for analyzing endocrine related system regulation under massage intervention.

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BibTeX
@article{lao2026coupling,
  title = {{Coupling characteristics of endocrine regulation and system function under massage interventions.}},
  author = {Xiangting Lao and Jin Yang and Ting Huang and Bingcai Long and Wei Liao and Yufeng He},
  journal = {Frontiers in endocrinology},
  year = {2026},
  month = oct,
  doi = {10.3389/fendo.2026.1885282},
  url = {https://europepmc.org/article/MED/42908600},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Coupling characteristics of endocrine regulation and system function under massage interventions.
AU  - Xiangting Lao
AU  - Jin Yang
AU  - Ting Huang
AU  - Bingcai Long
AU  - Wei Liao
AU  - Yufeng He
PY  - 2026
DA  - 2026/10/07
JO  - Frontiers in endocrinology
DO  - 10.3389/fendo.2026.1885282
UR  - https://europepmc.org/article/MED/42908600
AB  - Introduction  Massage may influence stress related endocrine activity and systemic physiological function, but its dynamic regulatory effects remain difficult to quantify.Methods  This study develops a VariationalMotionBayesian framework to model endocrine related physiological responses under massage intervention. The framework combines mathematical formulation of coupled endocrine and systemic variables, variational latent representation learning, motion field estimation, Bayesian evidence aggregation, and physiological constraint regularization. Multimodal wearable physiological time series are used to infer latent regulatory states and predict individual stress status.Results and discussion  Experiments on WESAD and SWELL-KW show that the proposed model outperforms conventional machine learning, deep learning, and time series classification baselines in Accuracy, Macro F1, Balanced Accuracy, and AUROC. A controlled human massage intervention pilot study further shows coordinated changes in salivary cortisol, salivary alpha amylase, heart rate, RMSSD, electrodermal activity, respiration rate, and skin temperature after massage, and these measured responses are correlated with model derived latent dynamics. These results indicate that the proposed framework can capture physiologically meaningful temporal responses and provide a computational tool for analyzing endocrine related system regulation under massage intervention.
SN  - 1664-2392
ER  -