Peer-reviewedCC BY-NC-NDCirculation Journal
Longitudinal Transcriptomic Analysis Identifies Persistent Immune-Related Signature Associated With Restrictive Left Ventricular Filling Patterns After Heart Transplantation
Abstract
BACKGROUND: Diastolic dysfunction is a recognized chronic allograft complication, and a restrictive left ventricular filling pattern is associated with adverse outcomes. However, the underlying pathophysiological mechanisms remain unclear. METHODS AND RESULTS: <0.05), in the restrictive group at 5 years. Temporal analysis revealed that these pathways were downregulated from 1 to 5 years in the non-restrictive group but remained persistently activated in the restrictive group. CONCLUSIONS: The development of a restrictive filling pattern is associated with elevated intracardiac pressures and a persistent immune-related transcriptome signature, despite no histological evidence of rejection.
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BibTeX
@article{takahari2026longitudinal,
title = {{Longitudinal Transcriptomic Analysis Identifies Persistent Immune-Related Signature Associated With Restrictive Left Ventricular Filling Patterns After Heart Transplantation}},
author = {Kosuke Takahari and Tatsuya Shiraki and Hidetaka Kioka and Daisuke Nakamura and Yasuhiro Akazawa and Kei Nakamoto and Yuki Kuramoto and Hibiki Mima and Fusako Sera and Yasuharu Takeda and Yasumasa Tsukamoto and Isamu Mizote and Yusuke Adachi and Tomoyo Hamana and Tomohito Ohtani and Shigeru Miyagawa and Yasushi Sakata},
journal = {Circulation Journal},
year = {2026},
month = oct,
doi = {10.1253/circj.cj-26-0427},
url = {https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0427/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Longitudinal Transcriptomic Analysis Identifies Persistent Immune-Related Signature Associated With Restrictive Left Ventricular Filling Patterns After Heart Transplantation
AU - Kosuke Takahari
AU - Tatsuya Shiraki
AU - Hidetaka Kioka
AU - Daisuke Nakamura
AU - Yasuhiro Akazawa
AU - Kei Nakamoto
AU - Yuki Kuramoto
AU - Hibiki Mima
AU - Fusako Sera
AU - Yasuharu Takeda
AU - Yasumasa Tsukamoto
AU - Isamu Mizote
AU - Yusuke Adachi
AU - Tomoyo Hamana
AU - Tomohito Ohtani
AU - Shigeru Miyagawa
AU - Yasushi Sakata
PY - 2026
DA - 2026/10/23
JO - Circulation Journal
DO - 10.1253/circj.cj-26-0427
UR - https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0427/_article
AB - BACKGROUND: Diastolic dysfunction is a recognized chronic allograft complication, and a restrictive left ventricular filling pattern is associated with adverse outcomes. However, the underlying pathophysiological mechanisms remain unclear. METHODS AND RESULTS: <0.05), in the restrictive group at 5 years. Temporal analysis revealed that these pathways were downregulated from 1 to 5 years in the non-restrictive group but remained persistently activated in the restrictive group. CONCLUSIONS: The development of a restrictive filling pattern is associated with elevated intracardiac pressures and a persistent immune-related transcriptome signature, despite no histological evidence of rejection.
SN - 1347-4820
SN - 1346-9843
ER -