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Peer-reviewedCC BY 4.0PLOS One

Superior cervical gangliectomy exacerbates the aortic dissection in mice

  • Zhonghui Zhu1
  • Hao Jin2
  • Jie Li3
  • Li Yu4
  • Meifang Cao
  • Tao Jiang
  • Yi Jin
  • Baohong Jiang
4 affiliations
  1. 1Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
  2. 2School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China
  3. 3School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
  4. 4Shenzhen Institute for Drug Control (Shenzhen Testing Center of Medical Devices), Shenzhen, China
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Abstract

Background: Sympathetic innervation is fundamentally required for physiological aortic homeostasis. Though it plays a vital important role in aortic function, its specific role in aortic dissection (AD) remains unclear. Methods and results: In this study, we explored the role of the sympathetic nervous system in AD by examining the effects of superior cervical ganglionectomy (SCGx) in mice. Using β-aminopropionitrile (BAPN) induced AD mice model at pre-lesional stage, the tyrosine hydroxylase (TH) expression, indicative of sympathetic activity, increased early in AD progression and correlated with aortic elastic lamina degradation. SCGx did not affect aortic structure within 2 weeks without BAPN treatment, but bilateral SCGx exacerbated AD severity, increasing rupture rates and tear range after BAPN and angiotensin II (AngII) treatment. Conclusions: These findings highlighted the role of sympathetic nervous system in early AD stages and suggested bilateral SCGx may negatively impact AD progression. Furthermore, we found a trend toward smooth muscle cell phenotypic transformation after implementing SCGx in AD, revealing the integrity of the SCG played a pivotal role in preserving aortic homeostasis.

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Cite

BibTeXRIS
BibTeX
@article{zhu2026superior,
  title = {{Superior cervical gangliectomy exacerbates the aortic dissection in mice}},
  author = {Zhonghui Zhu and Hao Jin and Jie Li and Li Yu and Meifang Cao and Tao Jiang and Yi Jin and Baohong Jiang},
  journal = {PLOS One},
  year = {2026},
  month = sep,
  doi = {10.1371/journal.pone.0357281},
  url = {https://doi.org/10.1371/journal.pone.0357281},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Superior cervical gangliectomy exacerbates the aortic dissection in mice
AU  - Zhonghui Zhu
AU  - Hao Jin
AU  - Jie Li
AU  - Li Yu
AU  - Meifang Cao
AU  - Tao Jiang
AU  - Yi Jin
AU  - Baohong Jiang
PY  - 2026
DA  - 2026/09/01
JO  - PLOS One
DO  - 10.1371/journal.pone.0357281
UR  - https://doi.org/10.1371/journal.pone.0357281
AB  - Background: Sympathetic innervation is fundamentally required for physiological aortic homeostasis. Though it plays a vital important role in aortic function, its specific role in aortic dissection (AD) remains unclear. Methods and results: In this study, we explored the role of the sympathetic nervous system in AD by examining the effects of superior cervical ganglionectomy (SCGx) in mice. Using β-aminopropionitrile (BAPN) induced AD mice model at pre-lesional stage, the tyrosine hydroxylase (TH) expression, indicative of sympathetic activity, increased early in AD progression and correlated with aortic elastic lamina degradation. SCGx did not affect aortic structure within 2 weeks without BAPN treatment, but bilateral SCGx exacerbated AD severity, increasing rupture rates and tear range after BAPN and angiotensin II (AngII) treatment. Conclusions: These findings highlighted the role of sympathetic nervous system in early AD stages and suggested bilateral SCGx may negatively impact AD progression. Furthermore, we found a trend toward smooth muscle cell phenotypic transformation after implementing SCGx in AD, revealing the integrity of the SCG played a pivotal role in preserving aortic homeostasis.
SN  - 1932-6203
ER  -