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PreprintCC BYbioRxiv

Human body-site-stratified fungal genomic catalogs enhancing human mycobiome analysis

  • S. Ahn
  • J. Kim
  • I. Lee1
  1. 1Yonsei University
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Abstract

Current human mycobiome profiling relies largely on marker-based methods with limited sensitivity, whereas genome-based approaches require computationally intensive alignment against broad fungal references. Here, we present MycobiomeDB, a unified fungal genome catalog, and derive body-site-specific catalogs for the gut, oral cavity, skin, and vagina through metagenome-guided stratification. Using these catalogs, we developed site-specific MycoProfilers that improved taxonomic recall and better distinguished disease-associated mycobiomes from healthy controls than existing methods.

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Cite

BibTeXRIS
BibTeX
@misc{ahn2026human,
  title = {{Human body-site-stratified fungal genomic catalogs enhancing human mycobiome analysis}},
  author = {S. Ahn and J. Kim and I. Lee},
  howpublished = {bioRxiv},
  year = {2026},
  month = sep,
  doi = {10.64898/2026.09.20.752968},
  url = {https://www.biorxiv.org/content/10.64898/2026.09.20.752968v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Human body-site-stratified fungal genomic catalogs enhancing human mycobiome analysis
AU  - S. Ahn
AU  - J. Kim
AU  - I. Lee
PY  - 2026
DA  - 2026/09/20
PB  - bioRxiv
DO  - 10.64898/2026.09.20.752968
UR  - https://www.biorxiv.org/content/10.64898/2026.09.20.752968v1
AB  - Current human mycobiome profiling relies largely on marker-based methods with limited sensitivity, whereas genome-based approaches require computationally intensive alignment against broad fungal references. Here, we present MycobiomeDB, a unified fungal genome catalog, and derive body-site-specific catalogs for the gut, oral cavity, skin, and vagina through metagenome-guided stratification. Using these catalogs, we developed site-specific MycoProfilers that improved taxonomic recall and better distinguished disease-associated mycobiomes from healthy controls than existing methods.
ER  -