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Peer-reviewedCC BY 4.0Frontiers in Neuroscience

Research progress on the mechanism of microglia–astrocyte signal crosstalk in central sensitization of vestibular migraine

  • Tiancan Jin1,2,3
  • Weitao Wang1,2,3,4,5
  • Jinghan Qin1,2,3
  • Yaru Liu1,2,3
  • Xiaofei Fan1,2,3,4,5
  • Daopei Zhang1,2,3,4,5
  • Huailiang Zhang1,2,3,4,5
5 affiliations
  1. 1Department of Encephalopathy, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
  2. 2The First Clinical Medical College, Henan University of Traditional Chinese Medicine
  3. 3Henan Collaborative Innovation Center for Prevention and Treatment of Major Diseases with Integrated Traditional Chinese and Western Medicine
  4. 4Institute of Vertigo Diseases, Henan University of Traditional Chinese Medicine
  5. 5Henan Vertigo Disease Diagnosis and Treatment Center
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Abstract

Vestibular migraine (VM) is a vestibular disorder characterized by recurrent episodes of vertigo, frequently accompanied by headache, nausea, and vomiting, which substantially reduce patients’ quality of life. The pathogenesis of VM remains incompletely understood. Current studies mainly focus on ion channel dysfunction, trigeminovascular mechanisms, and genetic susceptibility. Increasing evidence suggests that neuroinflammation and central sensitization play important roles in the onset and maintenance of VM. Microglia and astrocytes are key mediators of central sensitization, and their bidirectional communication represents an important component of neuroimmune interactions in the central nervous system. Based on recent studies, this review systematically summarizes the interactions and crosstalk between microglia and astrocytes in central sensitization, aiming to provide further insight into the pathophysiology of VM and to explore potential preventive and therapeutic strategies.

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Cite

BibTeXRIS
BibTeX
@article{jin2026research,
  title = {{Research progress on the mechanism of microglia–astrocyte signal crosstalk in central sensitization of vestibular migraine}},
  author = {Tiancan Jin and Weitao Wang and Jinghan Qin and Yaru Liu and Xiaofei Fan and Daopei Zhang and Huailiang Zhang},
  journal = {Frontiers in Neuroscience},
  year = {2026},
  month = oct,
  doi = {10.3389/fnins.2026.1844932},
  url = {https://www.frontiersin.org/articles/10.3389/fnins.2026.1844932/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Research progress on the mechanism of microglia–astrocyte signal crosstalk in central sensitization of vestibular migraine
AU  - Tiancan Jin
AU  - Weitao Wang
AU  - Jinghan Qin
AU  - Yaru Liu
AU  - Xiaofei Fan
AU  - Daopei Zhang
AU  - Huailiang Zhang
PY  - 2026
DA  - 2026/10/23
JO  - Frontiers in Neuroscience
DO  - 10.3389/fnins.2026.1844932
UR  - https://www.frontiersin.org/articles/10.3389/fnins.2026.1844932/full
AB  - Vestibular migraine (VM) is a vestibular disorder characterized by recurrent episodes of vertigo, frequently accompanied by headache, nausea, and vomiting, which substantially reduce patients’ quality of life. The pathogenesis of VM remains incompletely understood. Current studies mainly focus on ion channel dysfunction, trigeminovascular mechanisms, and genetic susceptibility. Increasing evidence suggests that neuroinflammation and central sensitization play important roles in the onset and maintenance of VM. Microglia and astrocytes are key mediators of central sensitization, and their bidirectional communication represents an important component of neuroimmune interactions in the central nervous system. Based on recent studies, this review systematically summarizes the interactions and crosstalk between microglia and astrocytes in central sensitization, aiming to provide further insight into the pathophysiology of VM and to explore potential preventive and therapeutic strategies.
SN  - 1662-453X
SN  - 1662-4548
ER  -