Association between bone morphogenetic protein 2 and interleukin 6 in patients with acute coronary syndrome
- 1Department of Biochemistry, College of Medicine, University of Babylon, Babylon, Iraq
- 2College of Medicine, University of Babylon, Babylon, Iraq
Abstract
Objective: To investigate the association between serum concentrations of bone morphogenetic protein 2 (BMP2) and interleukin‑6 (IL‑6) in patients diagnosed with acute coronary syndrome (ACS).
Methods: A case‑control study was conducted at Merjan Teaching Hospital, Iraq, from November 2025 to February 2026. The study included 60 patients with ACS and 60 healthy controls. Serum BMP2 and IL‑6 levels were measured using enzyme‑linked immunosorbent assay (ELISA).
Results: ACS patients had significantly higher serum BMP2 (2.53±1.0 ng/L vs. 1.55±0.37 ng/L; p<0.0001) and IL‑6 (74.7±27.5 ng/mL vs. 48±10.3 ng/mL; p<0.0001) compared to controls. Receiver operating characteristic (ROC) analysis showed excellent diagnostic performance for BMP2 (area under the curve, AUC=0.86) and IL‑6 (AUC=0.88). IL‑6 levels differed significantly across ACS subtypes (p=0.0008), being highest in unstable angina (UA), whereas BMP2 levels showed no significant variation (p=0.61).
Conclusions: Elevated BMP2 and IL‑6 are strongly associated with ACS and reflect the interplay of inflammation and vascular dysfunction. Their high diagnostic accuracy supports their potential as clinical tools for risk stratification, although BMP2 does not differentiate between ACS subtypes.
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BibTeX
@article{ali2026association,
title = {{Association between bone morphogenetic protein 2 and interleukin 6 in patients with acute coronary syndrome}},
author = {Abbas Ali and Zinah Ali and Shokry Nasser},
journal = {Babcock University Medical Journal},
year = {2026},
month = oct,
doi = {10.38029/babcockuniv.med.j..v9is1.1594},
url = {https://doi.org/10.38029/babcockuniv.med.j..v9is1.1594},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Association between bone morphogenetic protein 2 and interleukin 6 in patients with acute coronary syndrome
AU - Abbas Ali
AU - Zinah Ali
AU - Shokry Nasser
PY - 2026
DA - 2026/10/01
JO - Babcock University Medical Journal
DO - 10.38029/babcockuniv.med.j..v9is1.1594
UR - https://doi.org/10.38029/babcockuniv.med.j..v9is1.1594
AB - Objective: To investigate the association between serum concentrations of bone morphogenetic protein 2 (BMP2) and interleukin‑6 (IL‑6) in patients diagnosed with acute coronary syndrome (ACS). Methods: A case‑control study was conducted at Merjan Teaching Hospital, Iraq, from November 2025 to February 2026. The study included 60 patients with ACS and 60 healthy controls. Serum BMP2 and IL‑6 levels were measured using enzyme‑linked immunosorbent assay (ELISA). Results: ACS patients had significantly higher serum BMP2 (2.53±1.0 ng/L vs. 1.55±0.37 ng/L; p<0.0001) and IL‑6 (74.7±27.5 ng/mL vs. 48±10.3 ng/mL; p<0.0001) compared to controls. Receiver operating characteristic (ROC) analysis showed excellent diagnostic performance for BMP2 (area under the curve, AUC=0.86) and IL‑6 (AUC=0.88). IL‑6 levels differed significantly across ACS subtypes (p=0.0008), being highest in unstable angina (UA), whereas BMP2 levels showed no significant variation (p=0.61). Conclusions: Elevated BMP2 and IL‑6 are strongly associated with ACS and reflect the interplay of inflammation and vascular dysfunction. Their high diagnostic accuracy supports their potential as clinical tools for risk stratification, although BMP2 does not differentiate between ACS subtypes.
SN - 2465-6666
SN - 2756-4657
ER -