Association of VCTE-derived liver parameters and MASLD subtypes with advanced cardiovascular-kidney-metabolic syndrome
4 affiliations
- 1Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong
- 2State Key Laboratory of Pharmaceutical Biotechnology, Li Ka Shing Faculty of Medicine, University of Hong Kong
- 3Department of Medicine and Therapeutics, The Chinese University of Hong Kong
- 4School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong
Abstract
Background and aims: In cardiovascular-kidney-metabolic (CKM) syndrome, metabolic dysfunction-associated steatotic liver disease (MASLD) is not included in its staging criteria. We aimed to evaluate the associations between vibration-controlled transient elastography (VCTE)-derived liver parameters and advanced CKM stages, and to examine whether the CKM profile differs among MASLD subtypes.
Methods: VCTE and cardio-metabolic assessments were conducted among individuals enrolled in the New Hong Kong Cardiovascular Risk Factor Prevalence Study (NCRISPS), an ongoing population-based cohort recruiting Chinese residents of Hong Kong SAR between 2019 and 2024.
Results: Among 3199 eligible participants, 37.2% had MASLD, with 34.4% having MASLD alone and 2.8% due to combined etiology. VCTE-derived controlled attenuation parameter (CAP), liver stiffness (LS), and FibroScan-AST (FAST) score each showed graded associations with advanced CKM stages (all P<0.05). Compared to participants without steatotic liver disease, those with MASLD alone (adjusted OR 1.44, 95% CI 1.07–1.94; P = 0.016) and MASLD due to combined etiology (adjusted OR 2.35, 95% CI 1.22–4.49; P = 0.010) were both associated with significantly higher odds of advanced CKM stages.
Conclusions: MASLD, with and without combined etiology, was associated with the presence of advanced CKM syndrome. VCTE-derived parameters including CAP, LS, and FAST score were all associated with advanced CKM stages in a graded manner and whether inclusion of these non-invasive markers improves CKM syndrome staging and classification warrants longitudinal evaluation.
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BibTeX
@article{li2026association,
title = {{Association of VCTE-derived liver parameters and MASLD subtypes with advanced cardiovascular-kidney-metabolic syndrome}},
author = {Lanlan Li and David Tak-Wai Lui and Carol Ho-Yi Fong and Lung-Yi Mak and Chloe Yu-Yan Cheung and Jimmy Ho-Cheung Mak and Aimin Xu and Jean Woo and Kathryn Choon-Beng Tan and Hung-Fat Tse and Tai-Hing Lam and Yu-Cho Woo and Bernard Man-Yung Cheung and Man-Fung Yuen and Karen Siu-Ling Lam and Chi-Ho Lee},
journal = {Frontiers in Endocrinology},
year = {2026},
month = nov,
doi = {10.3389/fendo.2026.1984746},
url = {https://www.frontiersin.org/articles/10.3389/fendo.2026.1984746/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Association of VCTE-derived liver parameters and MASLD subtypes with advanced cardiovascular-kidney-metabolic syndrome
AU - Lanlan Li
AU - David Tak-Wai Lui
AU - Carol Ho-Yi Fong
AU - Lung-Yi Mak
AU - Chloe Yu-Yan Cheung
AU - Jimmy Ho-Cheung Mak
AU - Aimin Xu
AU - Jean Woo
AU - Kathryn Choon-Beng Tan
AU - Hung-Fat Tse
AU - Tai-Hing Lam
AU - Yu-Cho Woo
AU - Bernard Man-Yung Cheung
AU - Man-Fung Yuen
AU - Karen Siu-Ling Lam
AU - Chi-Ho Lee
PY - 2026
DA - 2026/11/09
JO - Frontiers in Endocrinology
DO - 10.3389/fendo.2026.1984746
UR - https://www.frontiersin.org/articles/10.3389/fendo.2026.1984746/full
AB - Background and aims: In cardiovascular-kidney-metabolic (CKM) syndrome, metabolic dysfunction-associated steatotic liver disease (MASLD) is not included in its staging criteria. We aimed to evaluate the associations between vibration-controlled transient elastography (VCTE)-derived liver parameters and advanced CKM stages, and to examine whether the CKM profile differs among MASLD subtypes. Methods: VCTE and cardio-metabolic assessments were conducted among individuals enrolled in the New Hong Kong Cardiovascular Risk Factor Prevalence Study (NCRISPS), an ongoing population-based cohort recruiting Chinese residents of Hong Kong SAR between 2019 and 2024. Results: Among 3199 eligible participants, 37.2% had MASLD, with 34.4% having MASLD alone and 2.8% due to combined etiology. VCTE-derived controlled attenuation parameter (CAP), liver stiffness (LS), and FibroScan-AST (FAST) score each showed graded associations with advanced CKM stages (all P<0.05). Compared to participants without steatotic liver disease, those with MASLD alone (adjusted OR 1.44, 95% CI 1.07–1.94; P = 0.016) and MASLD due to combined etiology (adjusted OR 2.35, 95% CI 1.22–4.49; P = 0.010) were both associated with significantly higher odds of advanced CKM stages. Conclusions: MASLD, with and without combined etiology, was associated with the presence of advanced CKM syndrome. VCTE-derived parameters including CAP, LS, and FAST score were all associated with advanced CKM stages in a graded manner and whether inclusion of these non-invasive markers improves CKM syndrome staging and classification warrants longitudinal evaluation.
SN - 1664-2392
ER -