A lipidomics roadmap: from basic research to societal challenges

@article{fedorova2026lipidomics,
  title = {{A lipidomics roadmap: from basic research to societal challenges}},
  author = {Maria Fedorova and Anne K. Bendt and Justine Bertrand‐Michel and Oliver Fiehn and Joanna Godzień and Laura Goracci and Florian Gruber and Xue Li Guan and Xianlin Han and Michal Holčapek and Julia Kuligowski and Peter J. Meikle and Palina Nepachalovich and Valerie B. O’Donnell and Matej Orešič and Sider Penkov and Snježana Petrović and Anton Potapov and Patricia Prabutzki and Laura Righetti and Tatjana Ruskovska and Andrej Shevchenko and Kai Simons and Corinne Michelle Spickett and Olga Vvedenskaya and Jennifer Watts and Markus Rene Wenk and Michael A. Witting and Yu Xia and B.Z. Yang and Maria Rosário Domingues},
  journal = {Nature Communications},
  year = {2026},
  month = may,
  doi = {10.1038/s41467-026-73797-4},
  url = {https://doi.org/10.1038/s41467-026-73797-4},
  note = {CC BY-NC-ND},
}

TY  - JOUR
TI  - A lipidomics roadmap: from basic research to societal challenges
AU  - Maria Fedorova
AU  - Anne K. Bendt
AU  - Justine Bertrand‐Michel
AU  - Oliver Fiehn
AU  - Joanna Godzień
AU  - Laura Goracci
AU  - Florian Gruber
AU  - Xue Li Guan
AU  - Xianlin Han
AU  - Michal Holčapek
AU  - Julia Kuligowski
AU  - Peter J. Meikle
AU  - Palina Nepachalovich
AU  - Valerie B. O’Donnell
AU  - Matej Orešič
AU  - Sider Penkov
AU  - Snježana Petrović
AU  - Anton Potapov
AU  - Patricia Prabutzki
AU  - Laura Righetti
AU  - Tatjana Ruskovska
AU  - Andrej Shevchenko
AU  - Kai Simons
AU  - Corinne Michelle Spickett
AU  - Olga Vvedenskaya
AU  - Jennifer Watts
AU  - Markus Rene Wenk
AU  - Michael A. Witting
AU  - Yu Xia
AU  - B.Z. Yang
AU  - Maria Rosário Domingues
PY  - 2026
DA  - 2026/05/28
JO  - Nature Communications
DO  - 10.1038/s41467-026-73797-4
UR  - https://doi.org/10.1038/s41467-026-73797-4
AB  - Lipidomics, a rapidly evolving discipline at the interface of biology and analytical chemistry, seeks to comprehensively characterize the lipid composition of biological systems. Driven by advances in mass spectrometry, chromatography and computational analysis, lipidomics has enabled the high-resolution mapping of lipid networks and their functional dynamics across molecular, cellular and organismal scales. In biomedical research, lipidomics is emerging as a powerful platform for biomarker discovery, enabling early diagnosis, prognosis, and therapeutic monitoring of cancer, metabolic, and neurodegenerative diseases. The field is also reshaping drug discovery by uncovering lipid-mediated pathways, identifying novel therapeutic targets, and refining assessments of drug efficacy and safety. Beyond medicine, lipidomic analyses are redefining food and nutrition science by elucidating how dietary lipids influence metabolic health and disease risk. In parallel, environmental and ecological lipidomics are emerging as powerful frameworks for assessing ecosystem health, tracking the impact of pollutants and exploring the biological consequences of climate change. Such approaches are also informing the discovery of sustainable lipid resources and the development of novel biotechnological and agricultural innovations. With its rapidly expanding analytical repertoire and cross-disciplinary relevance, lipidomics is poised to make substantial contributions to both fundamental biology and applied science. This Perspective aims to synthesise the current state of the field, delineate major analytical and conceptual challenges, and outline future directions for translating lipidomic knowledge into tangible societal and environmental benefits.
SN  - 2041-1723
ER  -