Retinal vasculature changes after 0.125% atropine treatment in children with myopia measured using optical coherence tomography angiography: A pilot study
Abstract
Purpose: The study assessed the microvascular changes in the retina after the use of 0.125% atropine in children with myopia and the association between retinal microvascular changes and the effects of myopia treatment. Materials and Methods: This is a prospective cohort study. Children with myopia aged 5–18 years old were included in the study. Retina microvascular parameters were measured with spectral domain optical coherence tomography (OCT) and OCT angiography devices during the follow-up. The main outcome measurements include vessel density of the superficial vascular plexus (SVP), deep vascular plexus, and axial length (AL). Results: A total of 64 eyes of 36 patients were included. A significant decrease in parafoveal vessel density of the SVP was observed in the first 3 months (P = 0.032). The change in parafoveal vessel density of the SVP in the first 3 months correlated negatively with the change in the AL after 1 year (r = −0.430, P = 0.028). Conclusion: These results suggest that 0.125% atropine might induce changes in the retina vasculature in children with myopia and that these changes might correlate with myopia progression. Nevertheless, as a pilot study, this result may need to be confirmed in larger studies.
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BibTeX
@article{huang2026retinal,
title = {{Retinal vasculature changes after 0.125% atropine treatment in children with myopia measured using optical coherence tomography angiography: A pilot study}},
author = {Yao-Chi Huang and Lan-Hsin Chuang and Ling Yeung and Hung-Chi Chen and Tsung-Hsien Tsai and Nan-Kai Wang and Po-Chun Chang and Yih-Shiou Hwang and Wei-Chi Wu and Chi-Chun Lai and Chun-Fu Liu},
journal = {Taiwan Journal of Ophthalmology},
year = {2026},
month = jul,
doi = {10.4103/tjo.tjo-d-25-00208},
url = {https://doi.org/10.4103/tjo.tjo-d-25-00208},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Retinal vasculature changes after 0.125% atropine treatment in children with myopia measured using optical coherence tomography angiography: A pilot study
AU - Yao-Chi Huang
AU - Lan-Hsin Chuang
AU - Ling Yeung
AU - Hung-Chi Chen
AU - Tsung-Hsien Tsai
AU - Nan-Kai Wang
AU - Po-Chun Chang
AU - Yih-Shiou Hwang
AU - Wei-Chi Wu
AU - Chi-Chun Lai
AU - Chun-Fu Liu
PY - 2026
DA - 2026/07/01
JO - Taiwan Journal of Ophthalmology
DO - 10.4103/tjo.tjo-d-25-00208
UR - https://doi.org/10.4103/tjo.tjo-d-25-00208
AB - Purpose: The study assessed the microvascular changes in the retina after the use of 0.125% atropine in children with myopia and the association between retinal microvascular changes and the effects of myopia treatment. Materials and Methods: This is a prospective cohort study. Children with myopia aged 5–18 years old were included in the study. Retina microvascular parameters were measured with spectral domain optical coherence tomography (OCT) and OCT angiography devices during the follow-up. The main outcome measurements include vessel density of the superficial vascular plexus (SVP), deep vascular plexus, and axial length (AL). Results: A total of 64 eyes of 36 patients were included. A significant decrease in parafoveal vessel density of the SVP was observed in the first 3 months (P = 0.032). The change in parafoveal vessel density of the SVP in the first 3 months correlated negatively with the change in the AL after 1 year (r = −0.430, P = 0.028). Conclusion: These results suggest that 0.125% atropine might induce changes in the retina vasculature in children with myopia and that these changes might correlate with myopia progression. Nevertheless, as a pilot study, this result may need to be confirmed in larger studies.
SN - 2211-5056
SN - 2211-5072
ER -