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Peer-reviewedCC BYFrontiers in medicine

The impact of allergic rhinitis on nasopharyngeal microbiota and metabolomics in children with severe adenoid hypertrophy

  • Binru Wang1
  • Tian Chen2
  • Shan Gao3
  • Hui Jin1
  • Gengtian Liang1
  • Guoqing Gong1
  • Longkai Xiao1
  1. 1Department of Otolaryngology Head and Neck Surgery, Wuhan Third Hospital (Tongren Hospital of Wuhan University) , ,
  2. 2Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University , , ,
  3. 3Department of Anesthesiology, Wuhan Third Hospital (Tongren Hospital of Wuhan University) , ,
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Abstract

Introduction

The impact of allergic rhinitis (AR) on adenoid hypertrophy (AH) in pediatric patients is unclear. This study aims to investigate the effects of AR on the nasopharyngeal microbiota and metabolomics of children with AH.Methods

16S rDNA sequencing and untargeted metabolomics were used to evaluate the nasopharyngeal microbiota and metabolomics characteristics of 9 children with AH complicated with AR (AH-AR group) and 9 children with AH without complicated AR (AH-nAR group).Results

The 16S rDNA sequencing results showed that compared with the AH-nAR group, the diversity of nasopharyngeal microbiota in the AH-AR group significantly increased, mainly manifested by a significant increase in Fusobacterium, Actinomyces, and Veillonella genera. Further metabolomics showed that compared with the AHnAR group, 140 metabolites were significantly reduced and 115 metabolites were significantly increased in the adenoid surface secretion samples of the AH-AR group. KEGG enrichment analysis showed significant changes in 12 metabolic pathways in the AH-AR group. In addition, Spearman correlation analysis revealed a significant correlation between altered bacterial genera and metabolites.Discussion

AR may promote AH in children through the nasopharyngeal microbiota and metabolites.

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Cite

BibTeXRIS
BibTeX
@article{wang2026impact,
  title = {{The impact of allergic rhinitis on nasopharyngeal microbiota and metabolomics in children with severe adenoid hypertrophy}},
  author = {Binru Wang and Tian Chen and Shan Gao and Hui Jin and Gengtian Liang and Guoqing Gong and Longkai Xiao},
  journal = {Frontiers in medicine},
  year = {2026},
  month = oct,
  doi = {10.3389/fmed.2026.1895589},
  url = {https://europepmc.org/article/PMC/PMC13717848},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The impact of allergic rhinitis on nasopharyngeal microbiota and metabolomics in children with severe adenoid hypertrophy
AU  - Binru Wang
AU  - Tian Chen
AU  - Shan Gao
AU  - Hui Jin
AU  - Gengtian Liang
AU  - Guoqing Gong
AU  - Longkai Xiao
PY  - 2026
DA  - 2026/10/15
JO  - Frontiers in medicine
DO  - 10.3389/fmed.2026.1895589
UR  - https://europepmc.org/article/PMC/PMC13717848
AB  - Introduction  The impact of allergic rhinitis (AR) on adenoid hypertrophy (AH) in pediatric patients is unclear. This study aims to investigate the effects of AR on the nasopharyngeal microbiota and metabolomics of children with AH.Methods  16S rDNA sequencing and untargeted metabolomics were used to evaluate the nasopharyngeal microbiota and metabolomics characteristics of 9 children with AH complicated with AR (AH-AR group) and 9 children with AH without complicated AR (AH-nAR group).Results  The 16S rDNA sequencing results showed that compared with the AH-nAR group, the diversity of nasopharyngeal microbiota in the AH-AR group significantly increased, mainly manifested by a significant increase in Fusobacterium, Actinomyces, and Veillonella genera. Further metabolomics showed that compared with the AHnAR group, 140 metabolites were significantly reduced and 115 metabolites were significantly increased in the adenoid surface secretion samples of the AH-AR group. KEGG enrichment analysis showed significant changes in 12 metabolic pathways in the AH-AR group. In addition, Spearman correlation analysis revealed a significant correlation between altered bacterial genera and metabolites.Discussion  AR may promote AH in children through the nasopharyngeal microbiota and metabolites.
SN  - 2296-858X
ER  -