Case Report: Successful treatment of generalized pustular psoriasis with concomitant renal insufficiency using spesolimab: a report of two cases
- 1Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology
- 2Hubei Province and Key Laboratory of Skin Infection and Immunity
- 3Wuhan No 1 Hospital
Abstract
Generalized pustular psoriasis (GPP) is a rare, severe, and potentially life-threatening neutrophilic dermatosis. Management focuses on rapid control of acute flares and prevention of recurrence. Advances in understanding the central role of interleukin-36 (IL-36) signaling in GPP pathogenesis have shifted the treatment paradigm from traditional systemic immunosuppressants toward targeted biologic therapies. This case report details two patients with GPP and comorbid renal insufficiency who achieved rapid and significant clinical improvement with spesolimab, an IL-36 receptor antagonist. Both patients presented with acute GPP flares and moderate renal impairment. Following a single 900 mg intravenous infusion of spesolimab, skin lesions and systemic symptoms resolved promptly, with disease stability maintained during follow-up. This report provides preliminary evidence supporting the efficacy and safety of spesolimab in this special patient population.
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BibTeX
@article{xie2026case,
title = {{Case Report: Successful treatment of generalized pustular psoriasis with concomitant renal insufficiency using spesolimab: a report of two cases}},
author = {You Xie and Feng Cheng and Zilu Qu and Lei Hu and Yun Xia and Liuqing Chen and Jinbo Chen},
journal = {Frontiers in Immunology},
year = {2026},
month = oct,
doi = {10.3389/fimmu.2026.1880139},
url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1880139/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Case Report: Successful treatment of generalized pustular psoriasis with concomitant renal insufficiency using spesolimab: a report of two cases
AU - You Xie
AU - Feng Cheng
AU - Zilu Qu
AU - Lei Hu
AU - Yun Xia
AU - Liuqing Chen
AU - Jinbo Chen
PY - 2026
DA - 2026/10/05
JO - Frontiers in Immunology
DO - 10.3389/fimmu.2026.1880139
UR - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1880139/full
AB - Generalized pustular psoriasis (GPP) is a rare, severe, and potentially life-threatening neutrophilic dermatosis. Management focuses on rapid control of acute flares and prevention of recurrence. Advances in understanding the central role of interleukin-36 (IL-36) signaling in GPP pathogenesis have shifted the treatment paradigm from traditional systemic immunosuppressants toward targeted biologic therapies. This case report details two patients with GPP and comorbid renal insufficiency who achieved rapid and significant clinical improvement with spesolimab, an IL-36 receptor antagonist. Both patients presented with acute GPP flares and moderate renal impairment. Following a single 900 mg intravenous infusion of spesolimab, skin lesions and systemic symptoms resolved promptly, with disease stability maintained during follow-up. This report provides preliminary evidence supporting the efficacy and safety of spesolimab in this special patient population.
SN - 1664-3224
ER -