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Peer-reviewedCC BY-NC 4.0Iranian Journal of Child Neurology

Age and Hemoglobin are Predictors of Febrile Seizure in Children under Five Years

  • Wienta Diarsvitri1
  • Pramita Anindya Nugraheni2
  • Verna Biutifasari3
  • Angela Puspita4
  • Vita Safira5
  • Nurlaili Istiqomah5
  • Nauroh Firdaus5
  • Albert Kurniawan6
  • Maria Steffany Lainama7
  • Ika Apriyanti Arum Putri5
  • Belinda Anasthasya Tansi5
  • Annisa Haslidianingsih5
7 affiliations
  1. 1Department of Community Medicine, Faculty of Medicine, Hang Tuah University, Surabaya 60244, Indonesia.
  2. 2Department of Pediatrics, Faculty of Medicine, Hang Tuah University/dr. Ramelan Central Naval Hospital, Surabaya 60244, Indonesia.
  3. 3Department of Clinical Pathology, Faculty of Medicine, Hang Tuah University, Surabaya 60244, Indonesia.
  4. 4Department of Emergency Medicine, Faculty of Medicine, Hang Tuah University, Surabaya 60244, Indonesia.
  5. 5Faculty of Medicine, Hang Tuah University, Surabaya 60244, Indonesia
  6. 6Department of Paediatrics, Faculty of Medicine, Lambung Mangkurat University/Ulin Hospital, Banjarmasin 70233, Indonesia.
  7. 7Department of Paediatrics, Faculty of Medicine, Udayana University/Prof. dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar 80113, Indonesia.
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Abstract

Objectives:: In resource-limited settings where the measurement of biomarkers of febrile seizures (FS) is difficult to carry out, it is essential to know the feasible factors associated with FS.

Materials & Methods:: This hospital-based case-control study was conducted based on 340 medical records of children aged six to 60 months who were hospitalized at the children’s ward of two hospitals in Indonesia, from 2019 to 2020. Data were analyzed using Mann-Whitney U, Chi-square tests, and logistic regression.

Results:: The case group had a higher proportion of males (59.4%) and a significantly younger median age of 24.3 months than the control group of 30.3 months (p = 0,003). Moreover, the case group had a significantly lower median hemoglobin level of 11.2 g/dL than the control group of 11.5 g/dL (p = 0.022). Each month, increasing age was associated with a reduced likelihood of exhibiting FS of 0.980-fold with a 95% CI (0.966, 0.995). Moreover, children with anemia were 2.350 times more likely to exhibit FS than those without anemia, 95% CI (1.399, 3.947).

Conclusion:: In low-resource settings. Younger age and reduced hemoglobin levels are useful indicators of febrile seizure risk in children under five, highlighting the importance of early detection and parental education.

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Cite

BibTeXRIS
BibTeX
@article{diarsvitri2026hemoglobin,
  title = {{Age and Hemoglobin are Predictors of Febrile Seizure in Children under Five Years}},
  author = {Wienta Diarsvitri and Pramita Anindya Nugraheni and Verna Biutifasari and Angela Puspita and Vita Safira and Nurlaili Istiqomah and Nauroh Firdaus and Albert Kurniawan and Maria Steffany Lainama and Ika Apriyanti Arum Putri and Belinda Anasthasya Tansi and Annisa Haslidianingsih},
  journal = {Iranian Journal of Child Neurology},
  year = {2026},
  month = sep,
  doi = {10.22037/ijcn.v20i4.46468},
  url = {https://doi.org/10.22037/ijcn.v20i4.46468},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Age and Hemoglobin are Predictors of Febrile Seizure in Children under Five Years
AU  - Wienta Diarsvitri
AU  - Pramita Anindya Nugraheni
AU  - Verna Biutifasari
AU  - Angela Puspita
AU  - Vita Safira
AU  - Nurlaili Istiqomah
AU  - Nauroh Firdaus
AU  - Albert Kurniawan
AU  - Maria Steffany Lainama
AU  - Ika Apriyanti Arum Putri
AU  - Belinda Anasthasya Tansi
AU  - Annisa Haslidianingsih
PY  - 2026
DA  - 2026/09/01
JO  - Iranian Journal of Child Neurology
DO  - 10.22037/ijcn.v20i4.46468
UR  - https://doi.org/10.22037/ijcn.v20i4.46468
AB  - Objectives:: In resource-limited settings where the measurement of biomarkers of febrile seizures (FS) is difficult to carry out, it is essential to know the feasible factors associated with FS.  Materials & Methods:: This hospital-based case-control study was conducted based on 340 medical records of children aged six to 60 months who were hospitalized at the children’s ward of two hospitals in Indonesia, from 2019 to 2020. Data were analyzed using Mann-Whitney U, Chi-square tests, and logistic regression.  Results:: The case group had a higher proportion of males (59.4%) and a significantly younger median age of 24.3 months than the control group of 30.3 months (p = 0,003). Moreover, the case group had a significantly lower median hemoglobin level of 11.2 g/dL than the control group of 11.5 g/dL (p = 0.022). Each month, increasing age was associated with a reduced likelihood of exhibiting FS of 0.980-fold with a 95% CI (0.966, 0.995). Moreover, children with anemia were 2.350 times more likely to exhibit FS than those without anemia, 95% CI (1.399, 3.947).  Conclusion:: In low-resource settings. Younger age and reduced hemoglobin levels are useful indicators of febrile seizure risk in children under five, highlighting the importance of early detection and parental education.
SN  - 1735-4668
SN  - 2008-0700
ER  -