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Peer-reviewedCC BYScience Advances

Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control

  • Nila K. van Overbeek1
  • Linda Clijsters1
  • Martina Wirth1
  • Ilona J. de Graaf1
  • Klaas de Lint2,3
  • Sidrit Uruci4
  • Amina F. A. S. Teunisse1
  • Vyacheslav Akimov5
  • Arnoud H. de Ru6
  • Maja Vukic4
  • Idil Kirdök2,3
  • Lucia Daxinger4
6 more authors
  • Peter A. van Veelen6
  • Blagoy Blagoev5
  • Martijn S. Luijsterburg4
  • Rob M. F. Wolthuis2,3
  • Ilana Berlin1,7
  • Alfred C. O. Vertegaal1
7 affiliations
  1. 1Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.
  2. 2Department of Human Genetics, Amsterdam University Medical Center, Amsterdam, Netherlands.
  3. 3Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, Netherlands.
  4. 4Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
  5. 5Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
  6. 6Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands.
  7. 7Oncode Institute, Leiden University Medical Center, Leiden, Netherlands.
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Cite

BibTeXRIS
BibTeX
@article{overbeek2026chemogenetic,
  title = {{Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control}},
  author = {Nila K. van Overbeek and Linda Clijsters and Martina Wirth and Ilona J. de Graaf and Klaas de Lint and Sidrit Uruci and Amina F. A. S. Teunisse and Vyacheslav Akimov and Arnoud H. de Ru and Maja Vukic and Idil Kirdök and Lucia Daxinger and Peter A. van Veelen and Blagoy Blagoev and Martijn S. Luijsterburg and Rob M. F. Wolthuis and Ilana Berlin and Alfred C. O. Vertegaal},
  journal = {Science Advances},
  year = {2026},
  month = oct,
  doi = {10.1126/sciadv.aea3388},
  url = {https://www.science.org/doi/10.1126/sciadv.aea3388},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control
AU  - Nila K. van Overbeek
AU  - Linda Clijsters
AU  - Martina Wirth
AU  - Ilona J. de Graaf
AU  - Klaas de Lint
AU  - Sidrit Uruci
AU  - Amina F. A. S. Teunisse
AU  - Vyacheslav Akimov
AU  - Arnoud H. de Ru
AU  - Maja Vukic
AU  - Idil Kirdök
AU  - Lucia Daxinger
AU  - Peter A. van Veelen
AU  - Blagoy Blagoev
AU  - Martijn S. Luijsterburg
AU  - Rob M. F. Wolthuis
AU  - Ilana Berlin
AU  - Alfred C. O. Vertegaal
PY  - 2026
DA  - 2026/10/16
JO  - Science Advances
DO  - 10.1126/sciadv.aea3388
UR  - https://www.science.org/doi/10.1126/sciadv.aea3388
SN  - 2375-2548
ER  -