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Peer-reviewedCC BY-NCInternational journal of general medicine

Predictive Value of P-Wave Dispersion Combined with Left Atrial Reservoir Strain for Incident Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy: A Retrospective Cohort Study.

  • Li Yu1,2
  • Yan Zhang1
  • Dandan Sun3
  • Aijie Hou2
  • Fei Xia2
  1. 1Internal Medicine, Dalian Medical University, Dalian, People's Republic of China.
  2. 2Department of Cardiovascular Medicine, Liaoning Provincial People's Hospital, Shenyang, People's Republic of China.
  3. 3Department of Ultrasound, Liaoning Provincial People's Hospital, Shenyang, People's Republic of China.
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Abstract

Purpose

Atrial fibrillation (AF) is the most common arrhythmia in patients with hypertrophic cardiomyopathy (HCM). This study aimed to investigate the associations of P-wave dispersion (PD) and left atrial reservoir strain (LASr) with incident AF.Methods

This single-center retrospective cohort study included 165 consecutive patients with HCM who were diagnosed at Liaoning Provincial People's Hospital from January 2018 to January 2026. Independent predictors of incident AF were identified using multivariable Cox regression. Model performance was assessed using a nomogram, time-dependent receiver operating characteristic curves, calibration curves, and decision curve analysis.Results

During a median follow-up of 1.79 years, 56 (33.9%) patients developed incident AF. PD (P=0.025) and LASr (P=0.028) were independently associated with incident AF. The combined PD + LASr model showed AUCs of 0.766, 0.764, and 0.823 at 1, 2, and 3 years, respectively. The model showed good calibration at 3 years and positive net benefit across clinically relevant threshold probabilities. Kaplan-Meier analysis showed a significantly higher cumulative incidence of AF in the high-risk group than in the low-risk group (log-rank P<0.001).Conclusion

PD and LASr are independently associated with AF risk in patients with HCM, and their combination may improve AF risk assessment.

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Cite

BibTeXRIS
BibTeX
@article{yu2026predictive,
  title = {{Predictive Value of P-Wave Dispersion Combined with Left Atrial Reservoir Strain for Incident Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy: A Retrospective Cohort Study.}},
  author = {Li Yu and Yan Zhang and Dandan Sun and Aijie Hou and Fei Xia},
  journal = {International journal of general medicine},
  year = {2026},
  month = oct,
  doi = {10.2147/ijgm.s646378},
  url = {https://europepmc.org/article/MED/42974149},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Predictive Value of P-Wave Dispersion Combined with Left Atrial Reservoir Strain for Incident Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy: A Retrospective Cohort Study.
AU  - Li Yu
AU  - Yan Zhang
AU  - Dandan Sun
AU  - Aijie Hou
AU  - Fei Xia
PY  - 2026
DA  - 2026/10/29
JO  - International journal of general medicine
DO  - 10.2147/ijgm.s646378
UR  - https://europepmc.org/article/MED/42974149
AB  - Purpose  Atrial fibrillation (AF) is the most common arrhythmia in patients with hypertrophic cardiomyopathy (HCM). This study aimed to investigate the associations of P-wave dispersion (PD) and left atrial reservoir strain (LASr) with incident AF.Methods  This single-center retrospective cohort study included 165 consecutive patients with HCM who were diagnosed at Liaoning Provincial People's Hospital from January 2018 to January 2026. Independent predictors of incident AF were identified using multivariable Cox regression. Model performance was assessed using a nomogram, time-dependent receiver operating characteristic curves, calibration curves, and decision curve analysis.Results  During a median follow-up of 1.79 years, 56 (33.9%) patients developed incident AF. PD (P=0.025) and LASr (P=0.028) were independently associated with incident AF. The combined PD + LASr model showed AUCs of 0.766, 0.764, and 0.823 at 1, 2, and 3 years, respectively. The model showed good calibration at 3 years and positive net benefit across clinically relevant threshold probabilities. Kaplan-Meier analysis showed a significantly higher cumulative incidence of AF in the high-risk group than in the low-risk group (log-rank P<0.001).Conclusion  PD and LASr are independently associated with AF risk in patients with HCM, and their combination may improve AF risk assessment.
SN  - 1178-7074
ER  -