Relationship between hyperuricemia and cardiovascular risk among postmenopausal women in cameroon: a community-based study.
7 affiliations
- 1Clinical Research Department, PRIMA SARL Laboratory, Yaoundé, Cameroon. [email protected].
- 2Public Health Department, Bora Africa Research Academy, Yaoundé, Cameroon. [email protected].
- 3Rheumatology Department, Central Hospital of Yaoundé, Yaoundé, Cameroon.
- 4Public Health Department, Bora Africa Research Academy, Yaoundé, Cameroon.
- 5Clinical Research Department, PRIMA SARL Laboratory, Yaoundé, Cameroon.
- 6Obstetrics and Gynaecology Department, Hospital Centre for Endoscopic Surgery and Human Reproduction, Yaoundé, Cameroon.
- 7Department of Clinical Biochemistry, Faculty of Medicine and Biomedical Sciences, University Teaching Hospital of Yaoundé, University of Yaoundé I, Yaoundé, Cameroon.
Abstract
Introduction
Despite the known association between hyperuricemia and an increased risk of cardiovascular disease, the prevalence and epidemiology of hyperuricemia in postmenopausal women in Cameroon are not yet fully understood. This study aimed to evaluate the prevalence of hyperuricemia, identify its associated factors, and examine its association with cardiovascular risk markers among postmenopausal women living in Yaoundé.Methods
A cross-sectional study was conducted in Yaoundé from November 2024 to June 2025, involving 206 postmenopausal women. Biological measurements were performed at PRIMA Lab using the Cobas 6000®. Independent associated factors with hyperuricemia were analyzed using logistic regression. Association between hyperuricemia and cardiovascular risk markers was assessed, using chi². The significance level was set at 5%. SPSS 28 was used for statistical analysis.Results
Out of 206 postmenopausal women, the mean age was 63.5 ± 8.7 [48-87] years. The prevalence of hyperuricemia was 37.9%. Menopausal duration ≥ 14 years (OR = 2.8; P = 0.016), overweight/obesity (OR = 1.9; P = 0.030) and hypertension (OR = 2.0; P = 0.036). Hyperuricemia was significantly associated with non-HDL cholesterol ≥ 130 mg/dL (P = 0.001), LDL/HDL ratio (P = 0.001), WHO CVR score ≥ 10% (P = 0.018), and non-HDL/total cholesterol ratio (P = 0.045).Conclusion
More than one-third of postmenopausal women have been diagnosed with hyperuricemia. Long duration of menopause, overweight/obesity and hypertension were independently associated with hyperuricemia. Hyperuricemia was significantly associate with non-HDL cholesterol, LDL/HDL ratio, non-HDL/total cholesterol ratio and WHO CVR score.
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BibTeX
@article{mbouna2026relationship,
title = {{Relationship between hyperuricemia and cardiovascular risk among postmenopausal women in cameroon: a community-based study.}},
author = {Stéphane Fargeon Massin Mbouna and Jan René Nkeck and Néri Ngole Atabe and Stéphane Yves Mbana Bikoi and Raphael Kinyuy Ndze and Emeraude Sorelle Mbock and Jean Maximilien Tang and Danielle Cécile Tang-Likeng and Claude Cyrille Ndoua Noa and Vicky Jocelyne Ama-Moor},
journal = {BMC cardiovascular disorders},
year = {2026},
month = jul,
doi = {10.1186/s12872-026-06335-1},
url = {https://europepmc.org/article/MED/42902136},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Relationship between hyperuricemia and cardiovascular risk among postmenopausal women in cameroon: a community-based study.
AU - Stéphane Fargeon Massin Mbouna
AU - Jan René Nkeck
AU - Néri Ngole Atabe
AU - Stéphane Yves Mbana Bikoi
AU - Raphael Kinyuy Ndze
AU - Emeraude Sorelle Mbock
AU - Jean Maximilien Tang
AU - Danielle Cécile Tang-Likeng
AU - Claude Cyrille Ndoua Noa
AU - Vicky Jocelyne Ama-Moor
PY - 2026
DA - 2026/07/01
JO - BMC cardiovascular disorders
DO - 10.1186/s12872-026-06335-1
UR - https://europepmc.org/article/MED/42902136
AB - Introduction Despite the known association between hyperuricemia and an increased risk of cardiovascular disease, the prevalence and epidemiology of hyperuricemia in postmenopausal women in Cameroon are not yet fully understood. This study aimed to evaluate the prevalence of hyperuricemia, identify its associated factors, and examine its association with cardiovascular risk markers among postmenopausal women living in Yaoundé.Methods A cross-sectional study was conducted in Yaoundé from November 2024 to June 2025, involving 206 postmenopausal women. Biological measurements were performed at PRIMA Lab using the Cobas 6000®. Independent associated factors with hyperuricemia were analyzed using logistic regression. Association between hyperuricemia and cardiovascular risk markers was assessed, using chi². The significance level was set at 5%. SPSS 28 was used for statistical analysis.Results Out of 206 postmenopausal women, the mean age was 63.5 ± 8.7 [48-87] years. The prevalence of hyperuricemia was 37.9%. Menopausal duration ≥ 14 years (OR = 2.8; P = 0.016), overweight/obesity (OR = 1.9; P = 0.030) and hypertension (OR = 2.0; P = 0.036). Hyperuricemia was significantly associated with non-HDL cholesterol ≥ 130 mg/dL (P = 0.001), LDL/HDL ratio (P = 0.001), WHO CVR score ≥ 10% (P = 0.018), and non-HDL/total cholesterol ratio (P = 0.045).Conclusion More than one-third of postmenopausal women have been diagnosed with hyperuricemia. Long duration of menopause, overweight/obesity and hypertension were independently associated with hyperuricemia. Hyperuricemia was significantly associate with non-HDL cholesterol, LDL/HDL ratio, non-HDL/total cholesterol ratio and WHO CVR score.
SN - 1471-2261
ER -