Living with Cancer under watch and wait: a qualitative systematic review and thematic synthesis.
- 1Institute of Mental Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
- 2Nottinghamshire Healthcare NHS Foundation Trust, Nottingham, United Kingdom.
- 3Psychological Health and Wellbeing Group, University of Lincoln, Lincoln, United Kingdom.
Abstract
Objective
Watchful waiting, sometimes referred to as active surveillance or observation, is used across a range of cancer contexts to avoid or delay unnecessary treatment and its associated harms. Although this approach may reduce overtreatment, it can also place patients in the unusual position of living with a known cancer that is being monitored rather than immediately treated. This may have important psychological and social consequences. The aim of this review was to synthesize qualitative research exploring patients' experiences of watchful waiting across cancer contexts.Methods
We conducted a qualitative systematic review and thematic synthesis of published studies examining patients' experiences of watchful waiting. Systematic searches were undertaken across major electronic databases and supplemented by hand searching. Eligible studies used qualitative methods and focused on the experiences of adults living with cancer under a watchful waiting, active surveillance, or equivalent monitoring pathway. Included studies were appraised for methodological quality, and findings were analysed using thematic synthesis to generate descriptive and higher order analytical themes.Results
Twenty five studies were included, representing a range of cancer types and clinical pathways. Five overarching themes were identified. First, patients described complex emotional responses, including shock, fear, anxiety, uncertainty, and, for some, gradual adaptation over time. Second, decision making was shaped by perceptions of risk, beliefs about treatment, and varying degrees of trust in clinicians and healthcare systems. Third, social experiences were often marked by isolation, misunderstanding, stigma, and strain within family and intimate relationships, particularly where others struggled to understand distress in the absence of active treatment. Fourth, patients drew on a range of coping strategies, including reassurance from monitoring, peer support, information seeking, acceptance, and routines. Fifth, communication and supportive care emerged as central, with patients valuing clear explanations, continuity, validation, and opportunities to discuss uncertainty and emotional burden.Conclusion
Watchful waiting is not a passive experience. It can be psychologically demanding and socially complex, even when clinically appropriate. Cancer services should recognize the emotional burden associated with living with untreated but monitored disease and should proactively identify patients who may benefit from clearer communication, reassurance, and tailored psychological or peer support.
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BibTeX
@article{boutry2026living,
title = {{Living with Cancer under watch and wait: a qualitative systematic review and thematic synthesis.}},
author = {Clement Boutry and Melissa Covington and Anika Kochar and Angel Nicholson and Naomi Thorpe and Nima Moghaddam},
journal = {Frontiers in psychology},
year = {2026},
month = oct,
doi = {10.3389/fpsyg.2026.1830770},
url = {https://europepmc.org/article/MED/42898263},
note = {CC BY},
}
RIS
TY - JOUR
TI - Living with Cancer under watch and wait: a qualitative systematic review and thematic synthesis.
AU - Clement Boutry
AU - Melissa Covington
AU - Anika Kochar
AU - Angel Nicholson
AU - Naomi Thorpe
AU - Nima Moghaddam
PY - 2026
DA - 2026/10/05
JO - Frontiers in psychology
DO - 10.3389/fpsyg.2026.1830770
UR - https://europepmc.org/article/MED/42898263
AB - Objective Watchful waiting, sometimes referred to as active surveillance or observation, is used across a range of cancer contexts to avoid or delay unnecessary treatment and its associated harms. Although this approach may reduce overtreatment, it can also place patients in the unusual position of living with a known cancer that is being monitored rather than immediately treated. This may have important psychological and social consequences. The aim of this review was to synthesize qualitative research exploring patients' experiences of watchful waiting across cancer contexts.Methods We conducted a qualitative systematic review and thematic synthesis of published studies examining patients' experiences of watchful waiting. Systematic searches were undertaken across major electronic databases and supplemented by hand searching. Eligible studies used qualitative methods and focused on the experiences of adults living with cancer under a watchful waiting, active surveillance, or equivalent monitoring pathway. Included studies were appraised for methodological quality, and findings were analysed using thematic synthesis to generate descriptive and higher order analytical themes.Results Twenty five studies were included, representing a range of cancer types and clinical pathways. Five overarching themes were identified. First, patients described complex emotional responses, including shock, fear, anxiety, uncertainty, and, for some, gradual adaptation over time. Second, decision making was shaped by perceptions of risk, beliefs about treatment, and varying degrees of trust in clinicians and healthcare systems. Third, social experiences were often marked by isolation, misunderstanding, stigma, and strain within family and intimate relationships, particularly where others struggled to understand distress in the absence of active treatment. Fourth, patients drew on a range of coping strategies, including reassurance from monitoring, peer support, information seeking, acceptance, and routines. Fifth, communication and supportive care emerged as central, with patients valuing clear explanations, continuity, validation, and opportunities to discuss uncertainty and emotional burden.Conclusion Watchful waiting is not a passive experience. It can be psychologically demanding and socially complex, even when clinically appropriate. Cancer services should recognize the emotional burden associated with living with untreated but monitored disease and should proactively identify patients who may benefit from clearer communication, reassurance, and tailored psychological or peer support.
SN - 1664-1078
ER -