Peer-reviewedCC BY-NC-NDInternal Medicine
MIP-1α and MIP-1ß as Potential Contributors to Bone Lesion Formation in Diffuse Large B-cell Lymphoma: A Case Report
Abstract
Bone involvement in malignant lymphoma is a critical poor prognostic factor; however, its molecular mechanisms remain poorly understood. A man in his 40s with diffuse large B-cell lymphoma presented with multiple extensive osteolytic lesions. Molecular and histopathological analyses revealed that the lymphoma cells were completely negative for major osteolytic factors, including RANKL, PTHrP, and DKK1. Conversely, the potent expression of MIP-1α and MIP-1ß was detected in these patients. This case suggests a possible novel, RANKL-independent mechanism of bone destruction mediated by the MIP-1 family in lymphoma, highlighting a potential therapeutic target that addresses both bone lysis and tumor progression.
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BibTeX
@article{minemura2026mip1α,
title = {{MIP-1α and MIP-1ß as Potential Contributors to Bone Lesion Formation in Diffuse Large B-cell Lymphoma: A Case Report}},
author = {Tomoki Minemura and Shohei Kikuchi and Takuma Fujihira and Ryusuke Horaguchi and Yoshimi Nabe and Nozomi Shinomiya and Kohei Kunimoto and Kento Ono and Yusuke Kamihara and Akinori Wada and Tsutomu Sato},
journal = {Internal Medicine},
year = {2026},
month = oct,
doi = {10.2169/internalmedicine.7952-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7952-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - MIP-1α and MIP-1ß as Potential Contributors to Bone Lesion Formation in Diffuse Large B-cell Lymphoma: A Case Report
AU - Tomoki Minemura
AU - Shohei Kikuchi
AU - Takuma Fujihira
AU - Ryusuke Horaguchi
AU - Yoshimi Nabe
AU - Nozomi Shinomiya
AU - Kohei Kunimoto
AU - Kento Ono
AU - Yusuke Kamihara
AU - Akinori Wada
AU - Tsutomu Sato
PY - 2026
DA - 2026/10/29
JO - Internal Medicine
DO - 10.2169/internalmedicine.7952-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7952-26/_article
AB - Bone involvement in malignant lymphoma is a critical poor prognostic factor; however, its molecular mechanisms remain poorly understood. A man in his 40s with diffuse large B-cell lymphoma presented with multiple extensive osteolytic lesions. Molecular and histopathological analyses revealed that the lymphoma cells were completely negative for major osteolytic factors, including RANKL, PTHrP, and DKK1. Conversely, the potent expression of MIP-1α and MIP-1ß was detected in these patients. This case suggests a possible novel, RANKL-independent mechanism of bone destruction mediated by the MIP-1 family in lymphoma, highlighting a potential therapeutic target that addresses both bone lysis and tumor progression.
SN - 1349-7235
SN - 0918-2918
ER -