Spruce-derived extracellular vesicles (SDEVs) improve hair loss by activating the proliferation of dermal papilla cells
- 1Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China
Abstract
Hair loss is a global health problem, and current conventional treatments, despite their effectiveness in delaying hair loss and improving hair growth, suffer from significant side effects and limitations in individualized treatment. In recent years, the application of novel nanotechnology in dermatology and regenerative medicine has gained attention. In this context, researchers explored the potential of applying Spruce-Derived Extracellular Vesicles (SDEVs) to hair loss intervention. Through in vitro experiments and in vivo animal models, it was found that Spruce-Derived Extracellular Vesicles (SDEVs) could improve hair follicles by activating the proliferation of Dermal papilla cells (DPCs) to intervene in hair loss. Spruce-Derived Extracellular Vesicles (SDEVs) significantly improved hair weight, thickness, and luster, and reduced the inflammatory response associated with hair loss compared with conventional treatments. These findings provide new ideas for hair regrowth treatments and demonstrate the potential therapeutic value of Spruce-Derived Extracellular Vesicles (SDEVs) in hair loss prevention.
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BibTeX
@article{zhang2026sprucederived,
title = {{Spruce-derived extracellular vesicles (SDEVs) improve hair loss by activating the proliferation of dermal papilla cells}},
author = {Kunchi Zhang and Ying Cao and Zitong Wang},
journal = {PLOS One},
year = {2026},
month = nov,
doi = {10.1371/journal.pone.0358041},
url = {https://doi.org/10.1371/journal.pone.0358041},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Spruce-derived extracellular vesicles (SDEVs) improve hair loss by activating the proliferation of dermal papilla cells
AU - Kunchi Zhang
AU - Ying Cao
AU - Zitong Wang
PY - 2026
DA - 2026/11/06
JO - PLOS One
DO - 10.1371/journal.pone.0358041
UR - https://doi.org/10.1371/journal.pone.0358041
AB - Hair loss is a global health problem, and current conventional treatments, despite their effectiveness in delaying hair loss and improving hair growth, suffer from significant side effects and limitations in individualized treatment. In recent years, the application of novel nanotechnology in dermatology and regenerative medicine has gained attention. In this context, researchers explored the potential of applying Spruce-Derived Extracellular Vesicles (SDEVs) to hair loss intervention. Through in vitro experiments and in vivo animal models, it was found that Spruce-Derived Extracellular Vesicles (SDEVs) could improve hair follicles by activating the proliferation of Dermal papilla cells (DPCs) to intervene in hair loss. Spruce-Derived Extracellular Vesicles (SDEVs) significantly improved hair weight, thickness, and luster, and reduced the inflammatory response associated with hair loss compared with conventional treatments. These findings provide new ideas for hair regrowth treatments and demonstrate the potential therapeutic value of Spruce-Derived Extracellular Vesicles (SDEVs) in hair loss prevention.
SN - 1932-6203
ER -